The role of glial-neuronal metabolic cooperation in modulating progression of multiple sclerosis and neuropathic pain

Rachel R. Robinson, Alina K. Dietz, Asif M. Maroof, Reto Asmis, Thomas G. Forsthuber

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

While the etiology of multiple sclerosis (MS) remains unclear, research from the clinic and preclinical models identified the essential role of inflammation and demyelination in the pathogenesis of MS. Current treatments focused on anti-inflammatory processes are effective against acute episodes and relapsing-remitting MS, but patients still move on to develop secondary progressive MS. MS progression is associated with activation of microglia and astrocytes, and importantly, metabolic dysfunction leading to neuronal death. Neuronal death also contributes to chronic neuropathic pain. Metabolic support of neurons by glia may play central roles in preventing progression of MS and chronic neuropathic pain. Here, we review mechanisms of metabolic cooperation between glia and neurons and outline future perspectives exploring metabolic support of neurons by glia.

Original languageEnglish (US)
Pages (from-to)129-147
Number of pages19
JournalImmunotherapy
Volume11
Issue number2
DOIs
StatePublished - Feb 2019
Externally publishedYes

Keywords

  • astrocyte
  • glia
  • metabolic coupling
  • microglia
  • multiple sclerosis
  • neuron
  • neuropathic pain
  • progressive
  • SPMS
  • virtual hypoxia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

Fingerprint

Dive into the research topics of 'The role of glial-neuronal metabolic cooperation in modulating progression of multiple sclerosis and neuropathic pain'. Together they form a unique fingerprint.

Cite this