The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human corpus cavernosum smooth muscle.

G. J. Christ, P. R. Brink, A. Melman, David C. Spray

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Intercellular communication through aqueous intercellular channels, known as gap junctions, has been postulated to provide an important mechanism for coordinating the rapid and synchronous responses of corporal smooth muscle during human penile erection and detumescence. Mathematical modeling analyses of drug diffusion were utilized to examine the potential physiological importance of the intercellular pathway to the regulation of smooth muscle tone in the human corpus cavernosum. In addition, patch clamp analyses and optical imaging studies were conducted to assess the ionic basis for cellular excitability and homeostasis in cultured corporal smooth muscle cells. In short, the computer modeling studies demonstrated that intercellular communication through gap junctions is likely to be the 'preferred' pathway for coordination of cellular activation and syncytial smooth muscle responses in this tissue. Moreover, the observed ion channel diversity reveals even further complexities to the modulation of corporal smooth muscle tone.

Original languageEnglish (US)
Pages (from-to)77-96
Number of pages20
JournalInternational journal of impotence research : official journal of the International Society for Impotence Research
Volume5
Issue number2
StatePublished - Jun 1993

Fingerprint

Gap Junctions
Ion Channels
Smooth Muscle
Penile Erection
Drug Design
Optical Imaging
Smooth Muscle Myocytes
Homeostasis

ASJC Scopus subject areas

  • Urology

Cite this

@article{c3bcbce9181d42ff959a456887b8dcdf,
title = "The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human corpus cavernosum smooth muscle.",
abstract = "Intercellular communication through aqueous intercellular channels, known as gap junctions, has been postulated to provide an important mechanism for coordinating the rapid and synchronous responses of corporal smooth muscle during human penile erection and detumescence. Mathematical modeling analyses of drug diffusion were utilized to examine the potential physiological importance of the intercellular pathway to the regulation of smooth muscle tone in the human corpus cavernosum. In addition, patch clamp analyses and optical imaging studies were conducted to assess the ionic basis for cellular excitability and homeostasis in cultured corporal smooth muscle cells. In short, the computer modeling studies demonstrated that intercellular communication through gap junctions is likely to be the 'preferred' pathway for coordination of cellular activation and syncytial smooth muscle responses in this tissue. Moreover, the observed ion channel diversity reveals even further complexities to the modulation of corporal smooth muscle tone.",
author = "Christ, {G. J.} and Brink, {P. R.} and A. Melman and Spray, {David C.}",
year = "1993",
month = "6",
language = "English (US)",
volume = "5",
pages = "77--96",
journal = "International Journal of Impotence Research",
issn = "0955-9930",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human corpus cavernosum smooth muscle.

AU - Christ, G. J.

AU - Brink, P. R.

AU - Melman, A.

AU - Spray, David C.

PY - 1993/6

Y1 - 1993/6

N2 - Intercellular communication through aqueous intercellular channels, known as gap junctions, has been postulated to provide an important mechanism for coordinating the rapid and synchronous responses of corporal smooth muscle during human penile erection and detumescence. Mathematical modeling analyses of drug diffusion were utilized to examine the potential physiological importance of the intercellular pathway to the regulation of smooth muscle tone in the human corpus cavernosum. In addition, patch clamp analyses and optical imaging studies were conducted to assess the ionic basis for cellular excitability and homeostasis in cultured corporal smooth muscle cells. In short, the computer modeling studies demonstrated that intercellular communication through gap junctions is likely to be the 'preferred' pathway for coordination of cellular activation and syncytial smooth muscle responses in this tissue. Moreover, the observed ion channel diversity reveals even further complexities to the modulation of corporal smooth muscle tone.

AB - Intercellular communication through aqueous intercellular channels, known as gap junctions, has been postulated to provide an important mechanism for coordinating the rapid and synchronous responses of corporal smooth muscle during human penile erection and detumescence. Mathematical modeling analyses of drug diffusion were utilized to examine the potential physiological importance of the intercellular pathway to the regulation of smooth muscle tone in the human corpus cavernosum. In addition, patch clamp analyses and optical imaging studies were conducted to assess the ionic basis for cellular excitability and homeostasis in cultured corporal smooth muscle cells. In short, the computer modeling studies demonstrated that intercellular communication through gap junctions is likely to be the 'preferred' pathway for coordination of cellular activation and syncytial smooth muscle responses in this tissue. Moreover, the observed ion channel diversity reveals even further complexities to the modulation of corporal smooth muscle tone.

UR - http://www.scopus.com/inward/record.url?scp=0027612799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027612799&partnerID=8YFLogxK

M3 - Article

C2 - 7688635

AN - SCOPUS:0027612799

VL - 5

SP - 77

EP - 96

JO - International Journal of Impotence Research

JF - International Journal of Impotence Research

SN - 0955-9930

IS - 2

ER -