The role of embryonic origin in preeclampsia

A comparison of autologous in vitro fertilization and ovum donor pregnancies

Peter C. Klatsky, Shani S. Delaney, Aaron B. Caughey, Nam D. Tran, Glenn L. Schattman, Zev Rosenwaks

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objective: To compare the risk of gestational hypertension and preeclampsia in pregnancies conceived through standard in vitro fertilization (IVF) using autologous oocytes with pregnancies conceived using donated oocytes. Methods: We conducted a retrospective, matched cohort study of women undergoing IVF using autologous compared with donor oocytes between 1998 and 2005. Women with live births resulting from oocyte donor pregnancies were matched for age and plurality (singleton or twin) with women undergoing autologous IVF. Primary outcomes were the incidence of preeclampsia or gestational hypertension (with and without proteinuria) in the third trimester. Data on preterm delivery, low birth weight, and embryo cryopreservation were also recorded. Results: Outcome data were available for 158 pregnancies, including 77 ovum-donor recipient pregnancies and 81 pregnancies using autologous oocytes. There were no differences in age, parity, and gestational type between the two cohorts. The incidence of gestational hypertension and preeclampsia was significantly higher in ovum-donor recipients compared with women undergoing autologous IVF (24.7% compared with 7.4%, P<.01, and 16.9% compared with 4.9%, P=.02, respectively). Ovum-donor recipients were more likely than women undergoing autologous IVF to deliver prematurely (34% compared with 19%). This association remained after controlling for multiple gestation (odds ratio 2.6, 95% confidence interval 1.04-6.3). Sixteen pregnancies from cryopreserved embryos were more likely to have hypertensive disorders of pregnancy (odds ratio 5.0, 95% confidence interval 1.2-20.5). Conclusion: Pregnancies derived from donor oocytes and cryopreserved-thawed embryos may be at a higher risk for hypertensive disorders of pregnancy. These findings inform future research and help counsel women using assisted reproductive technology.

Original languageEnglish (US)
Pages (from-to)1387-1392
Number of pages6
JournalObstetrics and Gynecology
Volume116
Issue number6
DOIs
StatePublished - Dec 2010
Externally publishedYes

Fingerprint

Fertilization in Vitro
Pre-Eclampsia
Tissue Donors
Pregnancy
Oocytes
Pregnancy Induced Hypertension
Embryonic Structures
Odds Ratio
Confidence Intervals
Assisted Reproductive Techniques
Cryopreservation
Incidence
Third Pregnancy Trimester
Live Birth
Low Birth Weight Infant
Parity
Proteinuria
Gestational Age
Cohort Studies

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

The role of embryonic origin in preeclampsia : A comparison of autologous in vitro fertilization and ovum donor pregnancies. / Klatsky, Peter C.; Delaney, Shani S.; Caughey, Aaron B.; Tran, Nam D.; Schattman, Glenn L.; Rosenwaks, Zev.

In: Obstetrics and Gynecology, Vol. 116, No. 6, 12.2010, p. 1387-1392.

Research output: Contribution to journalArticle

Klatsky, Peter C. ; Delaney, Shani S. ; Caughey, Aaron B. ; Tran, Nam D. ; Schattman, Glenn L. ; Rosenwaks, Zev. / The role of embryonic origin in preeclampsia : A comparison of autologous in vitro fertilization and ovum donor pregnancies. In: Obstetrics and Gynecology. 2010 ; Vol. 116, No. 6. pp. 1387-1392.
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