The role of DNA damage and repair in aging

New approaches to an old problem

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, various approaches have been taken to clarify the importance of preserving genome integrity for healthy aging. Here I will briefly review these approaches in the context of the progress made in improving our understanding of the interrelationship between DNA damage, genome maintenance and mutations.

Original languageEnglish (US)
Pages (from-to)498-502
Number of pages5
JournalMechanisms of Ageing and Development
Volume129
Issue number7-8
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

DNA Repair
DNA Damage
Repair
Genes
Aging of materials
Genome
DNA
Maintenance
Biological Phenomena
Mutation

Keywords

  • Aging
  • DNA damage
  • Genome maintenance
  • Life span
  • Mutation

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

The role of DNA damage and repair in aging : New approaches to an old problem. / Vijg, Jan.

In: Mechanisms of Ageing and Development, Vol. 129, No. 7-8, 07.2008, p. 498-502.

Research output: Contribution to journalArticle

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