The role of DNA damage and repair in aging: New approaches to an old problem

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, various approaches have been taken to clarify the importance of preserving genome integrity for healthy aging. Here I will briefly review these approaches in the context of the progress made in improving our understanding of the interrelationship between DNA damage, genome maintenance and mutations.

Original languageEnglish (US)
Pages (from-to)498-502
Number of pages5
JournalMechanisms of Ageing and Development
Issue number7-8
StatePublished - Jul 2008
Externally publishedYes


  • Aging
  • DNA damage
  • Genome maintenance
  • Life span
  • Mutation

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


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