The role of DNA damage and repair in aging: New approaches to an old problem

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, various approaches have been taken to clarify the importance of preserving genome integrity for healthy aging. Here I will briefly review these approaches in the context of the progress made in improving our understanding of the interrelationship between DNA damage, genome maintenance and mutations.

Original languageEnglish (US)
Pages (from-to)498-502
Number of pages5
JournalMechanisms of Ageing and Development
Volume129
Issue number7-8
DOIs
StatePublished - Jul 1 2008
Externally publishedYes

Keywords

  • Aging
  • DNA damage
  • Genome maintenance
  • Life span
  • Mutation

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Fingerprint Dive into the research topics of 'The role of DNA damage and repair in aging: New approaches to an old problem'. Together they form a unique fingerprint.

  • Cite this