The role of axonemal components in ciliary motility

Peter Satir

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

1. 1. The axoneme is the detergent-insoluble cytoskeleton of the cilium. 2. 2. All axonemes generate movement by the same fundamental mechanism: microtubule sliding utilizing ATP hydrolysis during a mechanochemical cycling of dynein arms on the axonemal doublets. 3. 3. Structure, fundamental biochemistry and physiology of the axoneme are conserved evolutionarily, but the phenotypes of beating movements and the responses to specific cytoplasmic signals differ greatly from organism to organism. 4. 4. A model of asynchronous dynein arm activity-the switch point hypothesis-has been proposed to account for cyclic beating in the face of unidirectional sliding. The model suggests that the diversity of beat phenotype may be explicable by changes in the timing of switching between active and inactive states of doublet arm activity. Evidence of axonemal splitting in arrested axonemes provides new support for the hypothesis.

Original languageEnglish (US)
Pages (from-to)351-357
Number of pages7
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume94
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Axoneme
Dyneins
Biochemistry
Physiology
Detergents
Hydrolysis
Adenosine Triphosphate
Switches
Phenotype
Cilia
Cytoskeleton
Microtubules

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Biochemistry

Cite this

The role of axonemal components in ciliary motility. / Satir, Peter.

In: Comparative Biochemistry and Physiology -- Part A: Physiology, Vol. 94, No. 2, 1989, p. 351-357.

Research output: Contribution to journalArticle

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