The role of autophagy in modulation of neuroinflammation in microglia

P. Su, J. Zhang, D. Wang, F. Zhao, Z. Cao, M. Aschner, W. Luo

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Microglia have multiple functions in regulating homeostasis in the central nervous system (CNS), and microglial inflammation is thought to play a role in the etiology of the neurodegenerative diseases. When endogenous or exogenous stimuli trigger disorders in microenvironmental homeostasis in CNS, microglia critically determine the fate of other neural cells. Recently, it was reported that autophagy might influence inflammation and activation of microglia. Though the interaction between autophagy and macrophages has been reported and reviewed in length, the role of autophagy in microglia has yet to be reviewed. Herein, we will highlight recent advances on the emerging role of autophagy in microglia, focusing on the regulation of autophagy during microglial inflammation, and the possible mechanism involved.

Original languageEnglish (US)
Pages (from-to)155-167
Number of pages13
JournalNeuroscience
Volume319
DOIs
StatePublished - Apr 5 2016

Keywords

  • Autophagy
  • Inflammation
  • Microglia

ASJC Scopus subject areas

  • Neuroscience(all)

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