The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy

Mohammad Behnam, Alireza Motamedzadeh, Marzieh Aalinezhad, Ehsan Dadgostar, Fatemeh Zahra Rashidi Noshabad, Mohammad Pourfridoni, Maedeh Raei, Hamed Mirzaei, Michael Aschner, Omid Reza Tamtaji

Research output: Contribution to journalReview articlepeer-review

Abstract

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.

Original languageEnglish (US)
JournalMolecular Biology Reports
DOIs
StateAccepted/In press - 2022

Keywords

  • Aquaporin 4
  • Astrocytoma
  • Glioblastoma
  • Glioma
  • Meningioma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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