TY - JOUR
T1 - The role of aquaporin 4 in brain tumors
T2 - implications for pathophysiology, diagnosis and therapy
AU - Behnam, Mohammad
AU - Motamedzadeh, Alireza
AU - Aalinezhad, Marzieh
AU - Dadgostar, Ehsan
AU - Rashidi Noshabad, Fatemeh Zahra
AU - Pourfridoni, Mohammad
AU - Raei, Maedeh
AU - Mirzaei, Hamed
AU - Aschner, Michael
AU - Tamtaji, Omid Reza
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature B.V.
PY - 2022/11
Y1 - 2022/11
N2 - Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.
AB - Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.
KW - Aquaporin 4
KW - Astrocytoma
KW - Glioblastoma
KW - Glioma
KW - Meningioma
UR - http://www.scopus.com/inward/record.url?scp=85132137830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85132137830&partnerID=8YFLogxK
U2 - 10.1007/s11033-022-07656-y
DO - 10.1007/s11033-022-07656-y
M3 - Review article
C2 - 35715607
AN - SCOPUS:85132137830
SN - 0301-4851
VL - 49
SP - 10609
EP - 10615
JO - Molecular Biology Reports
JF - Molecular Biology Reports
IS - 11
ER -