The role of antioxidants and vitamin A in ovarian cancer

Results from the women's health initiative

Cynthia A. Thomson, Marian L. Neuhouser, James M. Shikany, Bette J. Caan, Bradley J. Monk, Yasmin Mossavar-Rahmani, Gloria Sarto, Linda M. Parker, Francesmary Modugno, Garnet L. Anderson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Antioxidant nutrients and carotenoids have been inconsistently associated with ovarian cancer risk. We examined the relationship between intake of dietary and supplemental antioxidant nutrients including vitamins C, E, and selenium as well as carotenoids and vitamin A and ovarian cancer in 133,614 postmenopausal women enrolled in the Women's Health Initiative (WHI) study. Dietary intake was assessed using a food frequency questionnaire, and ovarian cancer endpoints were centrally adjudicated. Cox regression models were used to estimate the risk for invasive ovarian cancer in relation to each of the antioxidant nutrients and carotenoids under consideration using models stratified for a WHI study component. A total of 451 cases of invasive ovarian cancer were diagnosed over 8.3 yr of follow-up. Dietary intake at baseline was not significantly different for cases vs. controls. Cases reported greater intake of supplemental vitamin C (358.0 mg/day vs. 291.6 mg/day, respectively; P = 0.024). Multivariate modeling (P for trend) of the risk for developing ovarian cancer did not suggest any significant relationships among dietary factors and ovarian cancer risk. The results from this prospective study of well-nourished, postmenopausal women suggest that intake of dietary antioxidants, carotenoids, and vitamin A are not associated with a reduction in ovarian cancer risk.

Original languageEnglish (US)
Pages (from-to)710-719
Number of pages10
JournalNutrition and Cancer
Volume60
Issue number6
DOIs
StatePublished - Nov 2008

Fingerprint

Women's Health
Vitamin A
Ovarian Neoplasms
Antioxidants
Carotenoids
Food
Ascorbic Acid
Selenium
Vitamin E
Proportional Hazards Models
Prospective Studies

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Thomson, C. A., Neuhouser, M. L., Shikany, J. M., Caan, B. J., Monk, B. J., Mossavar-Rahmani, Y., ... Anderson, G. L. (2008). The role of antioxidants and vitamin A in ovarian cancer: Results from the women's health initiative. Nutrition and Cancer, 60(6), 710-719. https://doi.org/10.1080/01635580802233983

The role of antioxidants and vitamin A in ovarian cancer : Results from the women's health initiative. / Thomson, Cynthia A.; Neuhouser, Marian L.; Shikany, James M.; Caan, Bette J.; Monk, Bradley J.; Mossavar-Rahmani, Yasmin; Sarto, Gloria; Parker, Linda M.; Modugno, Francesmary; Anderson, Garnet L.

In: Nutrition and Cancer, Vol. 60, No. 6, 11.2008, p. 710-719.

Research output: Contribution to journalArticle

Thomson, CA, Neuhouser, ML, Shikany, JM, Caan, BJ, Monk, BJ, Mossavar-Rahmani, Y, Sarto, G, Parker, LM, Modugno, F & Anderson, GL 2008, 'The role of antioxidants and vitamin A in ovarian cancer: Results from the women's health initiative', Nutrition and Cancer, vol. 60, no. 6, pp. 710-719. https://doi.org/10.1080/01635580802233983
Thomson, Cynthia A. ; Neuhouser, Marian L. ; Shikany, James M. ; Caan, Bette J. ; Monk, Bradley J. ; Mossavar-Rahmani, Yasmin ; Sarto, Gloria ; Parker, Linda M. ; Modugno, Francesmary ; Anderson, Garnet L. / The role of antioxidants and vitamin A in ovarian cancer : Results from the women's health initiative. In: Nutrition and Cancer. 2008 ; Vol. 60, No. 6. pp. 710-719.
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