The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

Beatrice Goilav, Chaim Putterman

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalSeminars in Nephrology
Volume35
Issue number5
DOIs
StatePublished - 2015

Keywords

  • Anti-DNA antibodies
  • Cross-reactivity
  • Lupus nephritis
  • Nephritogenic antibodies

ASJC Scopus subject areas

  • Nephrology

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