The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

Research output: Contribution to journalArticle

13 Scopus citations


Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.

Original languageEnglish (US)
JournalSeminars in Nephrology
StateAccepted/In press - 2015



  • Anti-DNA antibodies
  • Cross-reactivity
  • Lupus nephritis
  • Nephritogenic antibodies

ASJC Scopus subject areas

  • Nephrology

Cite this