The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

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Abstract

Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.

Original languageEnglish (US)
JournalSeminars in Nephrology
DOIs
StateAccepted/In press - 2015

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Keywords

  • Anti-DNA antibodies
  • Cross-reactivity
  • Lupus nephritis
  • Nephritogenic antibodies

ASJC Scopus subject areas

  • Nephrology

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