The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis

Pierre Youinou, Chaim Putterman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Antibodies to double-stranded DNA are important in the pathogenesis of nephritis, a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes, identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding the disease, while monitoring their titer clinically may serve as an improved biomarker. Based upon work in animal models and crosssectional human studies, kidney a-actinin was thought to be a plausible cross-reactive target for pathogenic lupus antibodies. Manson and colleagues longitudinally evaluated anti-nucleosome, anti-DNA, and anti-a-actinin antibodies in 16 lupus patients with new-onset nephritis. While anti-nucleosome and anti-DNA antibody levels were significantly associated and correlated with measures of kidney disease, these were not found to be significant with anti- a-actinin antibodies. While in lupus patients the diagnostic use of serum anti-a-actinin antibodies, alone or with other novel biomarkers, is still under investigation, such studies are vital in improving our monitoring of systemic lupus erythematosus patients and in developing new treatment paradigms that meet the continuing clinical challenge of lupus nephritis.

Original languageEnglish (US)
Article number137
JournalArthritis Research and Therapy
Volume11
Issue number6
DOIs
StatePublished - Dec 11 2009

Fingerprint

Actinin
Lupus Nephritis
Anti-Idiotypic Antibodies
Antibodies
Nucleosomes
Nephritis
Biomarkers
Kidney
Antinuclear Antibodies
DNA
Kidney Diseases
Systemic Lupus Erythematosus
Autoantibodies
Early Diagnosis
Animal Models
Serum

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis. / Youinou, Pierre; Putterman, Chaim.

In: Arthritis Research and Therapy, Vol. 11, No. 6, 137, 11.12.2009.

Research output: Contribution to journalArticle

@article{079a0fe23f334780840a96394846fd79,
title = "The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis",
abstract = "Antibodies to double-stranded DNA are important in the pathogenesis of nephritis, a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes, identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding the disease, while monitoring their titer clinically may serve as an improved biomarker. Based upon work in animal models and crosssectional human studies, kidney a-actinin was thought to be a plausible cross-reactive target for pathogenic lupus antibodies. Manson and colleagues longitudinally evaluated anti-nucleosome, anti-DNA, and anti-a-actinin antibodies in 16 lupus patients with new-onset nephritis. While anti-nucleosome and anti-DNA antibody levels were significantly associated and correlated with measures of kidney disease, these were not found to be significant with anti- a-actinin antibodies. While in lupus patients the diagnostic use of serum anti-a-actinin antibodies, alone or with other novel biomarkers, is still under investigation, such studies are vital in improving our monitoring of systemic lupus erythematosus patients and in developing new treatment paradigms that meet the continuing clinical challenge of lupus nephritis.",
author = "Pierre Youinou and Chaim Putterman",
year = "2009",
month = "12",
day = "11",
doi = "10.1186/ar2869",
language = "English (US)",
volume = "11",
journal = "Arthritis Research and Therapy",
issn = "1478-6354",
publisher = "BioMed Central",
number = "6",

}

TY - JOUR

T1 - The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis

AU - Youinou, Pierre

AU - Putterman, Chaim

PY - 2009/12/11

Y1 - 2009/12/11

N2 - Antibodies to double-stranded DNA are important in the pathogenesis of nephritis, a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes, identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding the disease, while monitoring their titer clinically may serve as an improved biomarker. Based upon work in animal models and crosssectional human studies, kidney a-actinin was thought to be a plausible cross-reactive target for pathogenic lupus antibodies. Manson and colleagues longitudinally evaluated anti-nucleosome, anti-DNA, and anti-a-actinin antibodies in 16 lupus patients with new-onset nephritis. While anti-nucleosome and anti-DNA antibody levels were significantly associated and correlated with measures of kidney disease, these were not found to be significant with anti- a-actinin antibodies. While in lupus patients the diagnostic use of serum anti-a-actinin antibodies, alone or with other novel biomarkers, is still under investigation, such studies are vital in improving our monitoring of systemic lupus erythematosus patients and in developing new treatment paradigms that meet the continuing clinical challenge of lupus nephritis.

AB - Antibodies to double-stranded DNA are important in the pathogenesis of nephritis, a major clinical manifestation in lupus patients. Since earlier diagnosis of renal involvement may lead to better outcomes, identification of the nephritogenic specificity of lupus-associated autoantibodies is important in understanding the disease, while monitoring their titer clinically may serve as an improved biomarker. Based upon work in animal models and crosssectional human studies, kidney a-actinin was thought to be a plausible cross-reactive target for pathogenic lupus antibodies. Manson and colleagues longitudinally evaluated anti-nucleosome, anti-DNA, and anti-a-actinin antibodies in 16 lupus patients with new-onset nephritis. While anti-nucleosome and anti-DNA antibody levels were significantly associated and correlated with measures of kidney disease, these were not found to be significant with anti- a-actinin antibodies. While in lupus patients the diagnostic use of serum anti-a-actinin antibodies, alone or with other novel biomarkers, is still under investigation, such studies are vital in improving our monitoring of systemic lupus erythematosus patients and in developing new treatment paradigms that meet the continuing clinical challenge of lupus nephritis.

UR - http://www.scopus.com/inward/record.url?scp=77952513179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952513179&partnerID=8YFLogxK

U2 - 10.1186/ar2869

DO - 10.1186/ar2869

M3 - Article

C2 - 20017900

AN - SCOPUS:77952513179

VL - 11

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

SN - 1478-6354

IS - 6

M1 - 137

ER -