The role of anger/hostility in treatment-resistant depression: A secondary analysis from the ADAPT-A Study

Lauren B. Fisher, Maurizio Fava, Gheorghe D. Doros, Jonathan E. Alpert, Michael Henry, Ilana Huz, Marlene P. Freeman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Major depressive disorder is often accompanied by elevated levels of anger, hostility, and irritability, which may contribute to worse outcomes. The present study is a secondary analysis examining the role of anger/hostility in the treatment response to low-dose aripiprazole added to antidepressant therapy in 225 patients with major depressive disorder and inadequate response to antidepressant treatment. Repeated-measures model demonstrated no drug-placebo difference in treatment response across levels of anger/hostility. However, withingroup analyses showed significantly lower placebo response rates in patients with high anger/hostility and a trend for lower drug response rates in patientswith high anger/hostility. Pooled response rates across phases and treatments revealed a lower response rate among patients with high anger/hostility. Depressed patients with high anger/hostility demonstrate greater illness severity and lower depressive treatment response rates than patients with low anger/hostility, suggesting that patients with high anger/hostility may have poorer outcomes in response to adjunctive treatment.

Original languageEnglish (US)
Pages (from-to)762-768
Number of pages7
JournalJournal of Nervous and Mental Disease
Volume203
Issue number10
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Anger
  • Augmentation
  • Hostility
  • Treatment-resistant depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Medicine(all)

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