Abstract
Major depressive disorder is often accompanied by elevated levels of anger, hostility, and irritability, which may contribute to worse outcomes. The present study is a secondary analysis examining the role of anger/hostility in the treatment response to low-dose aripiprazole added to antidepressant therapy in 225 patients with major depressive disorder and inadequate response to antidepressant treatment. Repeated-measures model demonstrated no drug-placebo difference in treatment response across levels of anger/hostility. However, withingroup analyses showed significantly lower placebo response rates in patients with high anger/hostility and a trend for lower drug response rates in patientswith high anger/hostility. Pooled response rates across phases and treatments revealed a lower response rate among patients with high anger/hostility. Depressed patients with high anger/hostility demonstrate greater illness severity and lower depressive treatment response rates than patients with low anger/hostility, suggesting that patients with high anger/hostility may have poorer outcomes in response to adjunctive treatment.
Original language | English (US) |
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Pages (from-to) | 762-768 |
Number of pages | 7 |
Journal | Journal of Nervous and Mental Disease |
Volume | 203 |
Issue number | 10 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Keywords
- Anger
- Augmentation
- Hostility
- Treatment-resistant depression
ASJC Scopus subject areas
- Psychiatry and Mental health