The role of anger/hostility in treatment-resistant depression: A secondary analysis from the ADAPT-A Study

Lauren B. Fisher, Maurizio Fava, Gheorghe D. Doros, Jonathan E. Alpert, Michael Henry, Ilana Huz, Marlene P. Freeman

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Major depressive disorder is often accompanied by elevated levels of anger, hostility, and irritability, which may contribute to worse outcomes. The present study is a secondary analysis examining the role of anger/hostility in the treatment response to low-dose aripiprazole added to antidepressant therapy in 225 patients with major depressive disorder and inadequate response to antidepressant treatment. Repeated-measures model demonstrated no drug-placebo difference in treatment response across levels of anger/hostility. However, withingroup analyses showed significantly lower placebo response rates in patients with high anger/hostility and a trend for lower drug response rates in patientswith high anger/hostility. Pooled response rates across phases and treatments revealed a lower response rate among patients with high anger/hostility. Depressed patients with high anger/hostility demonstrate greater illness severity and lower depressive treatment response rates than patients with low anger/hostility, suggesting that patients with high anger/hostility may have poorer outcomes in response to adjunctive treatment.

Original languageEnglish (US)
Pages (from-to)762-768
Number of pages7
JournalJournal of Nervous and Mental Disease
Volume203
Issue number10
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Anger
  • Augmentation
  • Hostility
  • Treatment-resistant depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Medicine(all)

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