The role of amniotic fluid in influencing neonatal birth weight

Sathyaprasad Burjonrappa, E. Crete, S. Bouchard

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: We studied 123 neonates with atresias of the gastrointestinal tract at different levels to assess the role of amniotic fluid in the growth and development of the gastrointestinal tract. Our hypothesis was that significant differences in birth weight between groups otherwise comparable would suggest an intrauterine nutritive role for amniotic fluid. Our second hypothesis was that there is a trophic role of amniotic fluid on intestinal epithelium affecting its functional maturity. Establishing earlier tolerance of enteral nutrition in neonates with distal as compared with proximal atresias would support this hypothesis.Study Design: Overall, 123 neonates from a single institution, with duodenal atresia (DA), jejuno-ileal (JIA) and colonic atresia (CA), were separated into three groups. Birth weight, gestational age, associated anomalies and duration of total parenteral nutrition intake were recorded. Neonates with multiple atresias and gastroschisis were excluded from analysis. Statistical analysis of differences between groups was carried out using analysis of variance (ANOVA) for independent samples. Post-ANOVA pairwise comparisons were carried out using the Tukey-HSD test.Result: Fifty-four DAs, 62 JIAs and seven CAs were included. The mean birth weight, 2380.5 g (s.d. 988) in DA, 2814 g (s.d. 755) in JIA and 3153 g (s.d. 527) in CA were significantly different between groups (P = 0.011). The Tukey-HSD test showed that DA

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalJournal of Perinatology
Volume30
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

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Amniotic Fluid
Birth Weight
Gastrointestinal Tract
Analysis of Variance
Gastroschisis
Total Parenteral Nutrition
Enteral Nutrition
Intestinal Mucosa
Growth and Development
Gestational Age
Familial duodenal atresia
Colonic Atresia

Keywords

  • Amniotic fluid
  • Birth weight
  • Intestinal atresia

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

The role of amniotic fluid in influencing neonatal birth weight. / Burjonrappa, Sathyaprasad; Crete, E.; Bouchard, S.

In: Journal of Perinatology, Vol. 30, No. 1, 01.2010, p. 27-29.

Research output: Contribution to journalArticle

Burjonrappa, Sathyaprasad ; Crete, E. ; Bouchard, S. / The role of amniotic fluid in influencing neonatal birth weight. In: Journal of Perinatology. 2010 ; Vol. 30, No. 1. pp. 27-29.
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