The Renin-Angiotensin system and right ventricular structure and function

The MESA-Right ventricle study

Corey E. Ventetuolo, Joao A.C. Lima, R. Graham Barr, Michael R. Bristow, Emilia Bagiella, Harjit Chahal, Jorge Kizer, David J. Lederer, David A. Bluemke, Steven M. Kawut

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The pulmonary vasculature is an important site of renin-angiotensin metabolism. While angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (collectively AIABs) have a role in left ventricular (LV) disease, the impact of AIABs on right ventricular (RV) function is unknown. AIAB use was determined by medication inventory during the Multi-Ethnic Study of Atherosclerosis baseline examination. RV measures were obtained via cardiac magnetic resonance imaging. The relationship between AIAB use and RV measures was assessed using multivariable linear regression, stratified by race/ethnicity, and adjusted for multiple covariates. AIAB use was associated with lower RV mass (-0.7 g, 95% confidence interval [CI]-1.3 to-0.1, P=0.03) in African Americans (N=1012) after adjustment for multiple covariates including LV mass. Among Caucasians (N=1591), AIAB use was associated with larger RV end-diastolic volume (3.7 mL, 95% CI 0.7-6.8, P=0.02) after adjustment for LV volume. No significant associations were seen between AIAB use and other RV measures or in Hispanic or Chinese American participants. AIAB use was associated with RV morphology in a race-specific and LV-independent manner, suggesting the renin-angiotensin system may play a unique role in RV structure and function. The use of AIABs in those with RV dysfunction warrants further study.

Original languageEnglish (US)
Pages (from-to)379-386
Number of pages8
JournalPulmonary Circulation
Volume2
Issue number3
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Fingerprint

Right Ventricular Function
Renin-Angiotensin System
Heart Ventricles
Confidence Intervals
Right Ventricular Dysfunction
Asian Americans
Angiotensin Receptor Antagonists
Angiotensins
Hispanic Americans
Angiotensin-Converting Enzyme Inhibitors
Renin
African Americans
Stroke Volume
Linear Models
Atherosclerosis
Magnetic Resonance Imaging
Equipment and Supplies
Lung

Keywords

  • Angiotensin II receptor blockers
  • Angiotensin-converting enzyme inhibitor
  • Epidemiology
  • Renin-angiotensin system
  • Right ventricle

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ventetuolo, C. E., Lima, J. A. C., Barr, R. G., Bristow, M. R., Bagiella, E., Chahal, H., ... Kawut, S. M. (2012). The Renin-Angiotensin system and right ventricular structure and function: The MESA-Right ventricle study. Pulmonary Circulation, 2(3), 379-386. https://doi.org/10.4103/2045-8932.101657

The Renin-Angiotensin system and right ventricular structure and function : The MESA-Right ventricle study. / Ventetuolo, Corey E.; Lima, Joao A.C.; Barr, R. Graham; Bristow, Michael R.; Bagiella, Emilia; Chahal, Harjit; Kizer, Jorge; Lederer, David J.; Bluemke, David A.; Kawut, Steven M.

In: Pulmonary Circulation, Vol. 2, No. 3, 01.07.2012, p. 379-386.

Research output: Contribution to journalArticle

Ventetuolo, CE, Lima, JAC, Barr, RG, Bristow, MR, Bagiella, E, Chahal, H, Kizer, J, Lederer, DJ, Bluemke, DA & Kawut, SM 2012, 'The Renin-Angiotensin system and right ventricular structure and function: The MESA-Right ventricle study', Pulmonary Circulation, vol. 2, no. 3, pp. 379-386. https://doi.org/10.4103/2045-8932.101657
Ventetuolo, Corey E. ; Lima, Joao A.C. ; Barr, R. Graham ; Bristow, Michael R. ; Bagiella, Emilia ; Chahal, Harjit ; Kizer, Jorge ; Lederer, David J. ; Bluemke, David A. ; Kawut, Steven M. / The Renin-Angiotensin system and right ventricular structure and function : The MESA-Right ventricle study. In: Pulmonary Circulation. 2012 ; Vol. 2, No. 3. pp. 379-386.
@article{6112eb366602480689a2c581b466934e,
title = "The Renin-Angiotensin system and right ventricular structure and function: The MESA-Right ventricle study",
abstract = "The pulmonary vasculature is an important site of renin-angiotensin metabolism. While angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (collectively AIABs) have a role in left ventricular (LV) disease, the impact of AIABs on right ventricular (RV) function is unknown. AIAB use was determined by medication inventory during the Multi-Ethnic Study of Atherosclerosis baseline examination. RV measures were obtained via cardiac magnetic resonance imaging. The relationship between AIAB use and RV measures was assessed using multivariable linear regression, stratified by race/ethnicity, and adjusted for multiple covariates. AIAB use was associated with lower RV mass (-0.7 g, 95{\%} confidence interval [CI]-1.3 to-0.1, P=0.03) in African Americans (N=1012) after adjustment for multiple covariates including LV mass. Among Caucasians (N=1591), AIAB use was associated with larger RV end-diastolic volume (3.7 mL, 95{\%} CI 0.7-6.8, P=0.02) after adjustment for LV volume. No significant associations were seen between AIAB use and other RV measures or in Hispanic or Chinese American participants. AIAB use was associated with RV morphology in a race-specific and LV-independent manner, suggesting the renin-angiotensin system may play a unique role in RV structure and function. The use of AIABs in those with RV dysfunction warrants further study.",
keywords = "Angiotensin II receptor blockers, Angiotensin-converting enzyme inhibitor, Epidemiology, Renin-angiotensin system, Right ventricle",
author = "Ventetuolo, {Corey E.} and Lima, {Joao A.C.} and Barr, {R. Graham} and Bristow, {Michael R.} and Emilia Bagiella and Harjit Chahal and Jorge Kizer and Lederer, {David J.} and Bluemke, {David A.} and Kawut, {Steven M.}",
year = "2012",
month = "7",
day = "1",
doi = "10.4103/2045-8932.101657",
language = "English (US)",
volume = "2",
pages = "379--386",
journal = "Pulmonary Circulation",
issn = "2045-8932",
publisher = "University of Chicago Press",
number = "3",

}

TY - JOUR

T1 - The Renin-Angiotensin system and right ventricular structure and function

T2 - The MESA-Right ventricle study

AU - Ventetuolo, Corey E.

AU - Lima, Joao A.C.

AU - Barr, R. Graham

AU - Bristow, Michael R.

AU - Bagiella, Emilia

AU - Chahal, Harjit

AU - Kizer, Jorge

AU - Lederer, David J.

AU - Bluemke, David A.

AU - Kawut, Steven M.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - The pulmonary vasculature is an important site of renin-angiotensin metabolism. While angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (collectively AIABs) have a role in left ventricular (LV) disease, the impact of AIABs on right ventricular (RV) function is unknown. AIAB use was determined by medication inventory during the Multi-Ethnic Study of Atherosclerosis baseline examination. RV measures were obtained via cardiac magnetic resonance imaging. The relationship between AIAB use and RV measures was assessed using multivariable linear regression, stratified by race/ethnicity, and adjusted for multiple covariates. AIAB use was associated with lower RV mass (-0.7 g, 95% confidence interval [CI]-1.3 to-0.1, P=0.03) in African Americans (N=1012) after adjustment for multiple covariates including LV mass. Among Caucasians (N=1591), AIAB use was associated with larger RV end-diastolic volume (3.7 mL, 95% CI 0.7-6.8, P=0.02) after adjustment for LV volume. No significant associations were seen between AIAB use and other RV measures or in Hispanic or Chinese American participants. AIAB use was associated with RV morphology in a race-specific and LV-independent manner, suggesting the renin-angiotensin system may play a unique role in RV structure and function. The use of AIABs in those with RV dysfunction warrants further study.

AB - The pulmonary vasculature is an important site of renin-angiotensin metabolism. While angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (collectively AIABs) have a role in left ventricular (LV) disease, the impact of AIABs on right ventricular (RV) function is unknown. AIAB use was determined by medication inventory during the Multi-Ethnic Study of Atherosclerosis baseline examination. RV measures were obtained via cardiac magnetic resonance imaging. The relationship between AIAB use and RV measures was assessed using multivariable linear regression, stratified by race/ethnicity, and adjusted for multiple covariates. AIAB use was associated with lower RV mass (-0.7 g, 95% confidence interval [CI]-1.3 to-0.1, P=0.03) in African Americans (N=1012) after adjustment for multiple covariates including LV mass. Among Caucasians (N=1591), AIAB use was associated with larger RV end-diastolic volume (3.7 mL, 95% CI 0.7-6.8, P=0.02) after adjustment for LV volume. No significant associations were seen between AIAB use and other RV measures or in Hispanic or Chinese American participants. AIAB use was associated with RV morphology in a race-specific and LV-independent manner, suggesting the renin-angiotensin system may play a unique role in RV structure and function. The use of AIABs in those with RV dysfunction warrants further study.

KW - Angiotensin II receptor blockers

KW - Angiotensin-converting enzyme inhibitor

KW - Epidemiology

KW - Renin-angiotensin system

KW - Right ventricle

UR - http://www.scopus.com/inward/record.url?scp=85009832691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009832691&partnerID=8YFLogxK

U2 - 10.4103/2045-8932.101657

DO - 10.4103/2045-8932.101657

M3 - Article

VL - 2

SP - 379

EP - 386

JO - Pulmonary Circulation

JF - Pulmonary Circulation

SN - 2045-8932

IS - 3

ER -