The relationship between virus load response to highly active antiretroviral therapy and change in CD4 cell counts: A report from the Women's Interagency HIV Study

Jack A. DeHovitz, Andrea Kovacs, Joseph G. Feldman, Kathryn Anastos, Mary Young, Mardge Cohen, Stephen J. Gange, Sandra Melnick, Ruth M. Greenblatt

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The relationship between the pattern of virus load response to highly active antiretroviral therapy (HAART) and CD4 lymphocyte response was assessed in a cohort of 249 human immunodeficiency virus (HIV) type 1-infected women at 3 times: 1 before and 2 after initiation of therapy, with follow-up of 6-12 months. Patients with a durable response to HAART (i.e., >1 log decrease in HIV-1 RNA sustained for the study periods) had a continuous and significant increase in CD4 cell counts over time, whereas those with no response (<0.5 log decrease in HIV-1 RNA) had a slight decline. Patients with a mixed response (initial decrease >1 log, followed by a subsequent decrease <0.5 log) had an increase in CD4 cell count, followed by a plateau. The trend in CD4 cell count differed significantly by response to HAART, with those patients who experienced a durable response having significantly higher CD4 cell counts than others.

Original languageEnglish (US)
Pages (from-to)1527-1530
Number of pages4
JournalJournal of Infectious Diseases
Volume182
Issue number5
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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