The relationship between surface protease activity and the rate of cell proliferation in normal and transformed cells

Victor Bernard Hatcher, Martin S. Oberman, Michael S. Wertheim, Choo Y. Rhee, Grace Tsien, Peter G. Burk

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Surface protease activity and secreted protease activity has been determined on several cell lines utilizing 3H-acetyl casein as substrate. When normal rabbit aortic smooth muscle cells and fibroblasts stopped proliferating at high cell density a decrease in surface protease activity was observed. No decrease in surface protease activity or in the rate of cell proliferation was observed in either transformed melanoma or epidermal cells. The decrease of surface protease activity was related to a decrease in cell proliferation.

Original languageEnglish (US)
Pages (from-to)602-608
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume76
Issue number2
DOIs
StatePublished - May 23 1977

Fingerprint

Cell proliferation
Peptide Hydrolases
Cell Proliferation
Cells
Fibroblasts
Caseins
Smooth Muscle Myocytes
Muscle
Melanoma
Cell Count
Rabbits
Cell Line
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The relationship between surface protease activity and the rate of cell proliferation in normal and transformed cells. / Hatcher, Victor Bernard; Oberman, Martin S.; Wertheim, Michael S.; Rhee, Choo Y.; Tsien, Grace; Burk, Peter G.

In: Biochemical and Biophysical Research Communications, Vol. 76, No. 2, 23.05.1977, p. 602-608.

Research output: Contribution to journalArticle

Hatcher, Victor Bernard ; Oberman, Martin S. ; Wertheim, Michael S. ; Rhee, Choo Y. ; Tsien, Grace ; Burk, Peter G. / The relationship between surface protease activity and the rate of cell proliferation in normal and transformed cells. In: Biochemical and Biophysical Research Communications. 1977 ; Vol. 76, No. 2. pp. 602-608.
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