The relationship between surface protease activity and the rate of cell proliferation in normal and transformed cells

Victor B. Hatcher, Martin S. Oberman, Michael S. Wertheim, Choo Y. Rhee, Grace Tsien, Peter G. Burk

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31 Scopus citations


Surface protease activity and secreted protease activity has been determined on several cell lines utilizing 3H-acetyl casein as substrate. When normal rabbit aortic smooth muscle cells and fibroblasts stopped proliferating at high cell density a decrease in surface protease activity was observed. No decrease in surface protease activity or in the rate of cell proliferation was observed in either transformed melanoma or epidermal cells. The decrease of surface protease activity was related to a decrease in cell proliferation.

Original languageEnglish (US)
Pages (from-to)602-608
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - May 23 1977


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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