The regulatory C-terminal domain of subunit ε of FoF1 ATP synthase is dispensable for growth and survival of Escherichia coli

Naohiro Taniguchi, Toshiharu Suzuki, Michael Berney, Masasuke Yoshida, Gregory M. Cook

Research output: Contribution to journalComment/debate

10 Scopus citations

Abstract

The C-terminal domain of subunit ε of the bacterial FoF1 ATP synthase is reported to be an intrinsic inhibitor of ATP synthesis/hydrolysis activity in vitro, preventing wasteful hydrolysis of ATP under low-energy conditions. Mutants defective in this regulatory domain exhibited no significant difference in growth rate, molar growth yield, membrane potential, or intracellular ATP concentration under a wide range of growth conditions and stressors compared to wild-type cells, suggesting this inhibitory domain is dispensable for growth and survival of Escherichia coli.

Original languageEnglish (US)
Pages (from-to)2046-2052
Number of pages7
JournalJournal of Bacteriology
Volume193
Issue number8
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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