TY - JOUR
T1 - The regulation of class IA PI 3-kinases by inter-subunit interactions
AU - Backer, Jonathan M.
N1 - Funding Information:
This work was supported by NIH grants GM55692, DK07069, and 1 PO1 CA100324, and grants from American Diabetes Association and the Janey Fund. I thank Dr. Mirvat El-Sibai, Beirut University, for critical reading of the manuscript. I also thank Drs. Mark Girvin, Gary Gerfen, Steve Almo, and George Orr (deceased) at Albert Einstein College of Medicine, and Dr. Roger Williams at the MRC, Cambridge, for collaboration and hours of discussion over the past decade. Finally, I thank all my graduate students and postdocs for their scientific contributions to many of the studies cited here.
PY - 2010
Y1 - 2010
N2 - Phosphoinositide 3-kinases (PI 3-kinases) are activated by growth factor and hormone receptors, and regulate cell growth, survival, motility, and responses to changes in nutritional conditions (Engelman et al. 2006). PI 3-kinases have been classified according to their subunit composition and their substrate specificity for phosphoinositides (Vanhaesebroeck et al. 2001). The class IA PI 3-kinase is a heterodimer consisting of one regulatory subunit (p85α, p85β, p55α, p50α, or p55γ) and one 110-kDa catalytic subunit (p110a, b or d). The Class IB PI 3-kinase is also a dimer, composed of one regulatory subunit (p101 or p87) and one catalytic subunit (p110γ) (Wymann et al. 2003). Class I enzymes will utilize PI, PI[4]P, or PI[4,5]P2 as substrates in vitro, but are thought to primarily produce PI[3,4,5]P3 in cells.
AB - Phosphoinositide 3-kinases (PI 3-kinases) are activated by growth factor and hormone receptors, and regulate cell growth, survival, motility, and responses to changes in nutritional conditions (Engelman et al. 2006). PI 3-kinases have been classified according to their subunit composition and their substrate specificity for phosphoinositides (Vanhaesebroeck et al. 2001). The class IA PI 3-kinase is a heterodimer consisting of one regulatory subunit (p85α, p85β, p55α, p50α, or p55γ) and one 110-kDa catalytic subunit (p110a, b or d). The Class IB PI 3-kinase is also a dimer, composed of one regulatory subunit (p101 or p87) and one catalytic subunit (p110γ) (Wymann et al. 2003). Class I enzymes will utilize PI, PI[4]P, or PI[4,5]P2 as substrates in vitro, but are thought to primarily produce PI[3,4,5]P3 in cells.
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U2 - 10.1007/82-2010-52
DO - 10.1007/82-2010-52
M3 - Article
C2 - 20544340
AN - SCOPUS:79952113796
SN - 0070-217X
VL - 346
SP - 87
EP - 114
JO - Current Topics in Microbiology and Immunology
JF - Current Topics in Microbiology and Immunology
IS - 1
ER -