The rapid transbilayer movement of thiocholesterol in small unilamellar phospholipid vesicles

Eliezar A. Dawidowicz, Jonathan M. Backer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Cholesterol is a major component of biological membranes, yet there is very little information concerning its distribution across the membrane. Recent experiments in our laboratory, using cholesterol oxidase, have demonstrated that cholesterol can undergo a rapid transbilayer movement in lecithin-cholesterol vesicles in a half-time of 1 min or less at 37°C. In order to support this conclusion, we have sought other approaches to the measurement of this process. We now report our finding that the transbilayer movement of thiocholesterol in phospholipid vesicles occurs in a half-time of 1 min or less at 20°C.

Original languageEnglish (US)
Pages (from-to)373-375
Number of pages3
JournalBBA - Biomembranes
Volume644
Issue number2
DOIs
StatePublished - Jun 22 1981
Externally publishedYes

Keywords

  • Phospholipid vesicle
  • Thiocholesterol
  • Transbilayer movement

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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