Abstract
This study is to investigate the protective effects of the SB203580 against radiation induced mortality and intestinal injury of mice. A total of 67 male C57BL/6 mice (20.0-22.0 g) were matched according to body weight and randomly assigned to one of three groups: control, total body irradiation exposure (IR, 7.2Gy) only, and IR (7.2Gy) + SB203580 (15 mg·kg-1). 30 days survival rate was observed in the experiment. In intestinal injury experiment, the expression levels of caspase-3, Ki67, p53 and p-p38 were assayed in the mice intestine crypts. The results showed that the 30 days survival rate was 100% (control), 0 (IR) and 40% (IR+ SB203580), separately. Compared to the IR groups, the positive cells of caspase-3, p53 and p-p38 in crypt cells decreased 33.00%, 21.78% and 34.63%, respectively. The rate of positive cells of Ki67 increased 37.96%. Significant difference was found between all of them (P<0.01). SB203580 potently protected against radiation-induced lethal and intestinal injury in mice, and it may be a potential radio protector.
Original language | English (US) |
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Pages (from-to) | 395-399 |
Number of pages | 5 |
Journal | Yaoxue Xuebao |
Volume | 46 |
Issue number | 4 |
State | Published - Apr 12 2011 |
Externally published | Yes |
Keywords
- Apoptosis
- Radiation damage
- SB203580
- Survival rate
- p38 pathway
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- Molecular Medicine