The protective effect of mild hyperthermia against UV-mimetic agent 4-nitroquinoline-1-oxide (4NQO) in human colon cells

Hwa Jin Jung, Na Hwang Jee, Young R. Seo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hyperthermia-induced cellular response has been widely investigated for understanding cell physiology in stressful conditions as well as for therapeutic application using heat shock. In this study, the protective effect of mild hyperthermia-induced cellular response was investigated in RKO human colon cell lines, which harbor wild-type p53. Our data showed that the accumulation of p53 protein was induced without DNA damage in response to mild hyperthermia. Interestingly, the sub-lethal of heat shock at 40°C for 30 minutes in RKO cells showed the protective effect against UV mimetic agent 4-nitroquinoline-1- oxide (4NQO) with the decrease in mitotic index, although other papers had shown the induction of apoptosis in RKO cells under the higher dose of heat stress. Thus, we suggest that the protective effect of sub-lethal heat shock might be applicable for a novel preventive approach to clinical applications of mild hyperthermia.

Original languageEnglish (US)
Pages (from-to)123-133
Number of pages11
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume115-116
StatePublished - 2004
Externally publishedYes

Fingerprint

4-Nitroquinoline-1-oxide
Colon
Fever
Hot Temperature
Shock
Induced Hyperthermia
Cell Physiological Phenomena
Mitotic Index
DNA Damage
Apoptosis
Cell Line
Proteins

Keywords

  • 4-Nitroquinoline-1-oxide (4NQO)
  • Cellular response
  • DNA damage
  • Mild hyperthermia
  • Mitotic index
  • P53 protein
  • Protective effect of sub-lethal heat shock
  • RKO human cell lines
  • Stress

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pathology and Forensic Medicine

Cite this

The protective effect of mild hyperthermia against UV-mimetic agent 4-nitroquinoline-1-oxide (4NQO) in human colon cells. / Jung, Hwa Jin; Jee, Na Hwang; Seo, Young R.

In: Research Communications in Molecular Pathology and Pharmacology, Vol. 115-116, 2004, p. 123-133.

Research output: Contribution to journalArticle

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