The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade

Matthias Eikermann, Florian M. Vogt, Frank Herbstreit, Mehdi Vahid-Dastgerdi, Michael O. Zenge, Christof Ochterbeck, Armin De Greiff, Jürgen Peters

Research output: Contribution to journalArticlepeer-review

155 Scopus citations

Abstract

Rationale: Partial neuromuscular transmission failure by acetylcholine receptor blockade (neuromuscular blockade) or antibody-mediated functional loss (myasthenia gravis), even with a magnitude of muscle weakness that does not evoke respiratory symptoms, can evoke dysphagia and decreased inspiratory airflow, and increases the risk of susceptible patients to develop severe pulmonary complications. Objectives: To assess whether impaired neuromuscular transmission predisposes individuals to inspiratory upper airway collapse, we assessed supraglottic airway diameter and volume by respiratory-gated magnetic resonance imaging, upper airway dilator muscle function (genioglossus force and EMG), and changes in lung volume, respiratory timing, and peripheral muscle function before, during, and after partial neuromuscular blockade in healthy, awake volunteers. Measurements and Main Results: Partial neuromuscular blockade (train-of-four [TOF] ratio: 0.5 and 0.8) was associated with the following: (1) a decrease of inspiratory retropalatal and retroglossal upper airway volume to 66 ± 22 and 82 ± 12% of baseline, which was significantly more intense in the retropalatal area; (2) an attenuation of the normal increase in anteroposterior upper airway diameter during forced inspiration to 74 ± 18% of baseline; (3) a decrease in genioglossus activity during maximum voluntary tongue protrusion to 39 ± 19% (TOF, 0.5) and 73 ± 29% (TOF, 0.8) of baseline; and (4) no effects on upper airway size during expiration, lung volume, and respiratory timing. Conclusions: Thus, impaired neuromuscular transmission, even to a degree insufficient to evoke respiratory symptoms, markedly impairs upper airway dimensions and function. This may be explained by an impairment of the balance between upper airway dilating forces and negative intraluminal pressure generated during inspiration by respiratory "pump" muscles.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume175
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Keywords

  • Forced inspiration
  • Lung volume
  • Partial neuromuscular transmission failure
  • Upper airway dilator muscles
  • Upper airway size

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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