The predictive value of metabolic syndrome in patients with acute coronary syndrome after percutaneous coronary intervention

Tong Wen Sun, Qing Yan Xu, Hai Mu Yao, Fangxia Guan, Xiao Juan Zhang, Xueqin Hao, Jing Chao Zhang, Qiong Wu, Fei Peng, Fei Yang, Shang Chao Ma, Nan Nan Lu, Jin Ying Zhang, Quan Cheng Kan

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the predictive value of metabolic syndrome in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: A total of 660 patients with ACS admited to cardiovascular department, first affiliated hospital of zhengzhou university were enrolled in this study from January 2009 to June 2010. The enrollment criteria were: the stenosis degree were above 75% in at least one coronary artery by coronary angiography and successful PCI procedure. Exculsion criteria were: liver and renal insufficiency, malignancies and valvular heart diseases. The relevant clinical data and labtory examination were recorded after admission. The patients were followed up by outpatients interview or telephone from March to June 2011 and adverse cardiovascular events were recorded. The patients were divided into MS and non-MS groups, and basic clinical data were compared between two groups. The proportion difference between two groups were tested by chi square. Multivariate logistic regression was established to analyze the factors related to progonosis. The survival ratio was estimated using the Kaplan-Meier method. Statistical significance was established at a P value of less than 0. 05. Results: (1) A total of 606 (91.7%) patients successfully accepted follow-up. Mean follow-up time were (14.3 ± 1. 7) months. 95 patients experienced adverse cardiovascular events (15. 7%). (2) There were 393 patients (64. 96%) satisfied the definition of metabolic syndrome. The patients in MS group were with higher BMI, SBP, DBP, blood glucose and disordered lipid (all P <0. 05), with less fale patients (P =0. 016), less current somking (P = 0.008) and with higher platelet (P = 0.037). The incidence of adverse cardiovascular events in two groups were 17.81% and 11.79% (P > 0.05). (3) Multivarite logistic regression revealed that the predictors of adverse cardiovascular events were age [OR =2.628, 95% confidence interval (CI) 1.395-4.954, P = 0.003], New York Heart Association (NYHA) ≥3 grade (OR = 2. 310, 95% CI 1. 095 ∼ 4. 870, P = 0. 028) and left ventricular ejection fraction (LVEF) (OR = 4. 328, 95% CI 1. 955-9. 580, P <0. 001). However, MS was not related with prognosis (OR = 1. 170, 95% CI 0. 583-2. 345, P = 0. 659). (4) The cumulative survival rates of no adverse cardiovascular events in the two groups were no significant difference (P > 0. 05). Conclusions: MS is a risk factor with coronary heart disease. Howerer, it has no relationship with adverse cardiovascular events in patients with ACS after PCI.

Original languageEnglish (US)
Pages (from-to)1147-1152
Number of pages6
JournalChinese Journal of Emergency Medicine
Volume21
Issue number10
DOIs
StatePublished - Oct 10 2012
Externally publishedYes

Fingerprint

Percutaneous Coronary Intervention
Acute Coronary Syndrome
Confidence Intervals
Logistic Models
Hepatic Insufficiency
Heart Valve Diseases
Coronary Angiography
Stroke Volume
Statistical Factor Analysis
Renal Insufficiency
Coronary Disease
Blood Glucose
Coronary Vessels
Pathologic Constriction
Outpatients
Interviews
Lipids
Survival

Keywords

  • Acute coronary syndrome
  • Adverse cardiovascular events
  • Angioplasty
  • Metabolic syndrome, insulin resistance
  • Percutaneous coronary intervention
  • Prognosis

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency

Cite this

The predictive value of metabolic syndrome in patients with acute coronary syndrome after percutaneous coronary intervention. / Sun, Tong Wen; Xu, Qing Yan; Yao, Hai Mu; Guan, Fangxia; Zhang, Xiao Juan; Hao, Xueqin; Zhang, Jing Chao; Wu, Qiong; Peng, Fei; Yang, Fei; Ma, Shang Chao; Lu, Nan Nan; Zhang, Jin Ying; Kan, Quan Cheng.

In: Chinese Journal of Emergency Medicine, Vol. 21, No. 10, 10.10.2012, p. 1147-1152.

Research output: Contribution to journalArticle

Sun, TW, Xu, QY, Yao, HM, Guan, F, Zhang, XJ, Hao, X, Zhang, JC, Wu, Q, Peng, F, Yang, F, Ma, SC, Lu, NN, Zhang, JY & Kan, QC 2012, 'The predictive value of metabolic syndrome in patients with acute coronary syndrome after percutaneous coronary intervention', Chinese Journal of Emergency Medicine, vol. 21, no. 10, pp. 1147-1152. https://doi.org/10.3760/cma.j.issn.1671-0282.2012.10.019
Sun, Tong Wen ; Xu, Qing Yan ; Yao, Hai Mu ; Guan, Fangxia ; Zhang, Xiao Juan ; Hao, Xueqin ; Zhang, Jing Chao ; Wu, Qiong ; Peng, Fei ; Yang, Fei ; Ma, Shang Chao ; Lu, Nan Nan ; Zhang, Jin Ying ; Kan, Quan Cheng. / The predictive value of metabolic syndrome in patients with acute coronary syndrome after percutaneous coronary intervention. In: Chinese Journal of Emergency Medicine. 2012 ; Vol. 21, No. 10. pp. 1147-1152.
@article{a1fee0aae3ee4bcbb28cbdaf2426ef90,
title = "The predictive value of metabolic syndrome in patients with acute coronary syndrome after percutaneous coronary intervention",
abstract = "Objective: To investigate the predictive value of metabolic syndrome in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: A total of 660 patients with ACS admited to cardiovascular department, first affiliated hospital of zhengzhou university were enrolled in this study from January 2009 to June 2010. The enrollment criteria were: the stenosis degree were above 75{\%} in at least one coronary artery by coronary angiography and successful PCI procedure. Exculsion criteria were: liver and renal insufficiency, malignancies and valvular heart diseases. The relevant clinical data and labtory examination were recorded after admission. The patients were followed up by outpatients interview or telephone from March to June 2011 and adverse cardiovascular events were recorded. The patients were divided into MS and non-MS groups, and basic clinical data were compared between two groups. The proportion difference between two groups were tested by chi square. Multivariate logistic regression was established to analyze the factors related to progonosis. The survival ratio was estimated using the Kaplan-Meier method. Statistical significance was established at a P value of less than 0. 05. Results: (1) A total of 606 (91.7{\%}) patients successfully accepted follow-up. Mean follow-up time were (14.3 ± 1. 7) months. 95 patients experienced adverse cardiovascular events (15. 7{\%}). (2) There were 393 patients (64. 96{\%}) satisfied the definition of metabolic syndrome. The patients in MS group were with higher BMI, SBP, DBP, blood glucose and disordered lipid (all P <0. 05), with less fale patients (P =0. 016), less current somking (P = 0.008) and with higher platelet (P = 0.037). The incidence of adverse cardiovascular events in two groups were 17.81{\%} and 11.79{\%} (P > 0.05). (3) Multivarite logistic regression revealed that the predictors of adverse cardiovascular events were age [OR =2.628, 95{\%} confidence interval (CI) 1.395-4.954, P = 0.003], New York Heart Association (NYHA) ≥3 grade (OR = 2. 310, 95{\%} CI 1. 095 ∼ 4. 870, P = 0. 028) and left ventricular ejection fraction (LVEF) (OR = 4. 328, 95{\%} CI 1. 955-9. 580, P <0. 001). However, MS was not related with prognosis (OR = 1. 170, 95{\%} CI 0. 583-2. 345, P = 0. 659). (4) The cumulative survival rates of no adverse cardiovascular events in the two groups were no significant difference (P > 0. 05). Conclusions: MS is a risk factor with coronary heart disease. Howerer, it has no relationship with adverse cardiovascular events in patients with ACS after PCI.",
keywords = "Acute coronary syndrome, Adverse cardiovascular events, Angioplasty, Metabolic syndrome, insulin resistance, Percutaneous coronary intervention, Prognosis",
author = "Sun, {Tong Wen} and Xu, {Qing Yan} and Yao, {Hai Mu} and Fangxia Guan and Zhang, {Xiao Juan} and Xueqin Hao and Zhang, {Jing Chao} and Qiong Wu and Fei Peng and Fei Yang and Ma, {Shang Chao} and Lu, {Nan Nan} and Zhang, {Jin Ying} and Kan, {Quan Cheng}",
year = "2012",
month = "10",
day = "10",
doi = "10.3760/cma.j.issn.1671-0282.2012.10.019",
language = "English (US)",
volume = "21",
pages = "1147--1152",
journal = "Chinese Journal of Emergency Medicine",
issn = "1671-0282",
publisher = "Chinese Medical Association",
number = "10",

}

TY - JOUR

T1 - The predictive value of metabolic syndrome in patients with acute coronary syndrome after percutaneous coronary intervention

AU - Sun, Tong Wen

AU - Xu, Qing Yan

AU - Yao, Hai Mu

AU - Guan, Fangxia

AU - Zhang, Xiao Juan

AU - Hao, Xueqin

AU - Zhang, Jing Chao

AU - Wu, Qiong

AU - Peng, Fei

AU - Yang, Fei

AU - Ma, Shang Chao

AU - Lu, Nan Nan

AU - Zhang, Jin Ying

AU - Kan, Quan Cheng

PY - 2012/10/10

Y1 - 2012/10/10

N2 - Objective: To investigate the predictive value of metabolic syndrome in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: A total of 660 patients with ACS admited to cardiovascular department, first affiliated hospital of zhengzhou university were enrolled in this study from January 2009 to June 2010. The enrollment criteria were: the stenosis degree were above 75% in at least one coronary artery by coronary angiography and successful PCI procedure. Exculsion criteria were: liver and renal insufficiency, malignancies and valvular heart diseases. The relevant clinical data and labtory examination were recorded after admission. The patients were followed up by outpatients interview or telephone from March to June 2011 and adverse cardiovascular events were recorded. The patients were divided into MS and non-MS groups, and basic clinical data were compared between two groups. The proportion difference between two groups were tested by chi square. Multivariate logistic regression was established to analyze the factors related to progonosis. The survival ratio was estimated using the Kaplan-Meier method. Statistical significance was established at a P value of less than 0. 05. Results: (1) A total of 606 (91.7%) patients successfully accepted follow-up. Mean follow-up time were (14.3 ± 1. 7) months. 95 patients experienced adverse cardiovascular events (15. 7%). (2) There were 393 patients (64. 96%) satisfied the definition of metabolic syndrome. The patients in MS group were with higher BMI, SBP, DBP, blood glucose and disordered lipid (all P <0. 05), with less fale patients (P =0. 016), less current somking (P = 0.008) and with higher platelet (P = 0.037). The incidence of adverse cardiovascular events in two groups were 17.81% and 11.79% (P > 0.05). (3) Multivarite logistic regression revealed that the predictors of adverse cardiovascular events were age [OR =2.628, 95% confidence interval (CI) 1.395-4.954, P = 0.003], New York Heart Association (NYHA) ≥3 grade (OR = 2. 310, 95% CI 1. 095 ∼ 4. 870, P = 0. 028) and left ventricular ejection fraction (LVEF) (OR = 4. 328, 95% CI 1. 955-9. 580, P <0. 001). However, MS was not related with prognosis (OR = 1. 170, 95% CI 0. 583-2. 345, P = 0. 659). (4) The cumulative survival rates of no adverse cardiovascular events in the two groups were no significant difference (P > 0. 05). Conclusions: MS is a risk factor with coronary heart disease. Howerer, it has no relationship with adverse cardiovascular events in patients with ACS after PCI.

AB - Objective: To investigate the predictive value of metabolic syndrome in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: A total of 660 patients with ACS admited to cardiovascular department, first affiliated hospital of zhengzhou university were enrolled in this study from January 2009 to June 2010. The enrollment criteria were: the stenosis degree were above 75% in at least one coronary artery by coronary angiography and successful PCI procedure. Exculsion criteria were: liver and renal insufficiency, malignancies and valvular heart diseases. The relevant clinical data and labtory examination were recorded after admission. The patients were followed up by outpatients interview or telephone from March to June 2011 and adverse cardiovascular events were recorded. The patients were divided into MS and non-MS groups, and basic clinical data were compared between two groups. The proportion difference between two groups were tested by chi square. Multivariate logistic regression was established to analyze the factors related to progonosis. The survival ratio was estimated using the Kaplan-Meier method. Statistical significance was established at a P value of less than 0. 05. Results: (1) A total of 606 (91.7%) patients successfully accepted follow-up. Mean follow-up time were (14.3 ± 1. 7) months. 95 patients experienced adverse cardiovascular events (15. 7%). (2) There were 393 patients (64. 96%) satisfied the definition of metabolic syndrome. The patients in MS group were with higher BMI, SBP, DBP, blood glucose and disordered lipid (all P <0. 05), with less fale patients (P =0. 016), less current somking (P = 0.008) and with higher platelet (P = 0.037). The incidence of adverse cardiovascular events in two groups were 17.81% and 11.79% (P > 0.05). (3) Multivarite logistic regression revealed that the predictors of adverse cardiovascular events were age [OR =2.628, 95% confidence interval (CI) 1.395-4.954, P = 0.003], New York Heart Association (NYHA) ≥3 grade (OR = 2. 310, 95% CI 1. 095 ∼ 4. 870, P = 0. 028) and left ventricular ejection fraction (LVEF) (OR = 4. 328, 95% CI 1. 955-9. 580, P <0. 001). However, MS was not related with prognosis (OR = 1. 170, 95% CI 0. 583-2. 345, P = 0. 659). (4) The cumulative survival rates of no adverse cardiovascular events in the two groups were no significant difference (P > 0. 05). Conclusions: MS is a risk factor with coronary heart disease. Howerer, it has no relationship with adverse cardiovascular events in patients with ACS after PCI.

KW - Acute coronary syndrome

KW - Adverse cardiovascular events

KW - Angioplasty

KW - Metabolic syndrome, insulin resistance

KW - Percutaneous coronary intervention

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=84868311623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868311623&partnerID=8YFLogxK

U2 - 10.3760/cma.j.issn.1671-0282.2012.10.019

DO - 10.3760/cma.j.issn.1671-0282.2012.10.019

M3 - Article

VL - 21

SP - 1147

EP - 1152

JO - Chinese Journal of Emergency Medicine

JF - Chinese Journal of Emergency Medicine

SN - 1671-0282

IS - 10

ER -