Abstract
Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management.
Original language | English (US) |
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Pages (from-to) | 83-95 |
Number of pages | 13 |
Journal | JNCCN Journal of the National Comprehensive Cancer Network |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2008 |
Externally published | Yes |
Keywords
- CIN
- Cervical cancer
- Cervical intraepithelial neoplasia
- Cervical precancer
- Cytology
- HPV genotyping
- Human papillomavirus
ASJC Scopus subject areas
- Oncology