The potential utility of HPV genotyping in screening and clinical management

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management.

Original languageEnglish (US)
Pages (from-to)83-95
Number of pages13
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume6
Issue number1
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Uterine Cervical Neoplasms
Genotype
Human papillomavirus 18
Papillomavirus Infections
Human papillomavirus 16
Cell Biology

Keywords

  • Cervical cancer
  • Cervical intraepithelial neoplasia
  • Cervical precancer
  • CIN
  • Cytology
  • HPV genotyping
  • Human papillomavirus

ASJC Scopus subject areas

  • Oncology

Cite this

@article{d585f1ef46cf481aaab389ca0fc67829,
title = "The potential utility of HPV genotyping in screening and clinical management",
abstract = "Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management.",
keywords = "Cervical cancer, Cervical intraepithelial neoplasia, Cervical precancer, CIN, Cytology, HPV genotyping, Human papillomavirus",
author = "Castle, {Philip E.}",
year = "2008",
month = "1",
language = "English (US)",
volume = "6",
pages = "83--95",
journal = "Journal of the National Comprehensive Cancer Network : JNCCN",
issn = "1540-1405",
publisher = "Cold Spring Publishing LLC",
number = "1",

}

TY - JOUR

T1 - The potential utility of HPV genotyping in screening and clinical management

AU - Castle, Philip E.

PY - 2008/1

Y1 - 2008/1

N2 - Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management.

AB - Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management.

KW - Cervical cancer

KW - Cervical intraepithelial neoplasia

KW - Cervical precancer

KW - CIN

KW - Cytology

KW - HPV genotyping

KW - Human papillomavirus

UR - http://www.scopus.com/inward/record.url?scp=38949131442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38949131442&partnerID=8YFLogxK

M3 - Article

C2 - 18267061

AN - SCOPUS:38949131442

VL - 6

SP - 83

EP - 95

JO - Journal of the National Comprehensive Cancer Network : JNCCN

JF - Journal of the National Comprehensive Cancer Network : JNCCN

SN - 1540-1405

IS - 1

ER -