The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)

Young Rok Seo, Hwa Jin Jung

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The p53 tumor suppressor has long been envisaged to preserve genetic stability by the induction of cell cycle checkpoints and apoptosis. More recently, p53 has been implicated to play roles in DNA repair responses to genotoxic stresses. UV-damage and the damage caused by certain chemotherapeutics including cisplatin and nitrogen mustards are known to be repaired by the nucleotide excision repair (NER) pathway which is reportedly regulated by p53 and its downstream genes. There are evidences to suggest that the base excision repair (BER) induced by the base-damaging agent methyl methane-sulfonate (MMS) is partially deficient in cells lacking functional p53. This result suggests that the activity of BER might be also dependent on the p53 status. In this review, we discuss the possibilities that p53 regulates BER as well as NER; these are one of the most significant potentials of p53 tumor suppressor for repairing the vast majority of DNA damages that is incurred from various environmental stresses.

Original languageEnglish (US)
Pages (from-to)505-509
Number of pages5
JournalExperimental and Molecular Medicine
Volume36
Issue number6
StatePublished - Dec 31 2004
Externally publishedYes

Fingerprint

DNA Repair
Tumors
Repair
Nucleotides
Neoplasms
DNA Damage
Mechlorethamine
DNA
Methane
Cell Cycle Checkpoints
Cisplatin
Transcriptional Activation
Genes
Cells
Apoptosis

Keywords

  • DNA damage
  • DNA polymerase beta
  • DNA repair
  • DNA repair enzymes
  • Nucleotide excision repair (NER)
  • Protein p53

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER). / Seo, Young Rok; Jung, Hwa Jin.

In: Experimental and Molecular Medicine, Vol. 36, No. 6, 31.12.2004, p. 505-509.

Research output: Contribution to journalArticle

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