The potential role of natriuretic peptide-guided management for patients hospitalized for heart failure

Alan Maisel, Yang Xue, Stephen J. Greene, Peter S. Pang, James L. Januzzi, Ileana L. Piña, Christopher Defilippi, Javed Butler

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

There are >1 million hospitalizations for heart failure (HF) in the United States annually. After discharge, 25% of these patients are rehospitalized within 30 days, and 30% are dead within 1 year. To date, all trials in patients with acute HF (AHF) have failed to improve post-discharge outcomes. There remains a need for an effective objective risk stratification strategy that is capable of reliably identifying patients at heightened risk for readmission and informing discharge decision making. Natriuretic peptide (NP) levels during and after AHF hospitalization can provide valuable information regarding congestion status and chronic remodeling stress. The lack of sensitivity and inter-rater reliability of physical examination, and failure to achieve dry weight in many patients before discharge, renders the use of NP to guide therapy to prevent readmission an attractive option. NP levels can be used across the spectrum of AHF care settings, ranging from the emergency department and inpatient stay to post-discharge follow-up and chronic management. This review summarizes available data and provides an expert opinion on the potential role of NPs to reduce HF readmissions.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalJournal of Cardiac Failure
Volume21
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Heart failure
  • hospitalization
  • natriuretic peptides
  • readmission

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The potential role of natriuretic peptide-guided management for patients hospitalized for heart failure'. Together they form a unique fingerprint.

  • Cite this

    Maisel, A., Xue, Y., Greene, S. J., Pang, P. S., Januzzi, J. L., Piña, I. L., Defilippi, C., & Butler, J. (2015). The potential role of natriuretic peptide-guided management for patients hospitalized for heart failure. Journal of Cardiac Failure, 21(3), 233-239. https://doi.org/10.1016/j.cardfail.2014.11.009