The potential of nitric oxide releasing therapies as antimicrobial agents

David O. Schairer; Jason S. Chouake; Joshua D. Nosanchuk; Adam J. Friedman

doi:10.4161/viru.20328

The potential of nitric oxide releasing therapies as antimicrobial agents

David O. Schairer, Jason S. Chouake, Joshua D. Nosanchuk, Adam J. Friedman

Medicine

Research output: Contribution to journal › Review article › peer-review

404 Scopus citations

Abstract

Nitric oxide (NO) is a short-lived diatomic, lipophilic gas that plays an integral role in defending against pathogens. Among its many functions are involvement in immune cell signaling and in the biochemical reactions by which immune cells defend against bacteria, fungi, viruses and parasites. NO signaling directs a broad spectrum of processes, including the differentiation, proliferation, and apoptosis of immune cells. When secreted by activated immune cells, NO diffuses across cellular membranes and exacts nitrosative and oxidative damage on invading pathogens. These observations led to the development of NO delivery systems that can harness the antimicrobial properties of this evanescent gas. The innate microbicidal properties of NO, as well as the antimicrobial activity of the various NO delivery systems, are reviewed.

Original language	English (US)
Pages (from-to)	271-279
Number of pages	9
Journal	Virulence
Volume	3
Issue number	3
DOIs	https://doi.org/10.4161/viru.20328
State	Published - 2012

Keywords

Antibiotic
Antimicrobial
Nanotechnology
Nitric oxide

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/viru.20328

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abstract = "Nitric oxide (NO) is a short-lived diatomic, lipophilic gas that plays an integral role in defending against pathogens. Among its many functions are involvement in immune cell signaling and in the biochemical reactions by which immune cells defend against bacteria, fungi, viruses and parasites. NO signaling directs a broad spectrum of processes, including the differentiation, proliferation, and apoptosis of immune cells. When secreted by activated immune cells, NO diffuses across cellular membranes and exacts nitrosative and oxidative damage on invading pathogens. These observations led to the development of NO delivery systems that can harness the antimicrobial properties of this evanescent gas. The innate microbicidal properties of NO, as well as the antimicrobial activity of the various NO delivery systems, are reviewed.",

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AU - Chouake, Jason S.

AU - Nosanchuk, Joshua D.

AU - Friedman, Adam J.

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AB - Nitric oxide (NO) is a short-lived diatomic, lipophilic gas that plays an integral role in defending against pathogens. Among its many functions are involvement in immune cell signaling and in the biochemical reactions by which immune cells defend against bacteria, fungi, viruses and parasites. NO signaling directs a broad spectrum of processes, including the differentiation, proliferation, and apoptosis of immune cells. When secreted by activated immune cells, NO diffuses across cellular membranes and exacts nitrosative and oxidative damage on invading pathogens. These observations led to the development of NO delivery systems that can harness the antimicrobial properties of this evanescent gas. The innate microbicidal properties of NO, as well as the antimicrobial activity of the various NO delivery systems, are reviewed.

KW - Antibiotic

KW - Antimicrobial

KW - Nanotechnology

KW - Nitric oxide

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The potential of nitric oxide releasing therapies as antimicrobial agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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