The potential of nitric oxide releasing therapies as antimicrobial agents

David O. Schairer, Jason S. Chouake, Joshua D. Nosanchuk, Adam J. Friedman

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Nitric oxide (NO) is a short-lived diatomic, lipophilic gas that plays an integral role in defending against pathogens. Among its many functions are involvement in immune cell signaling and in the biochemical reactions by which immune cells defend against bacteria, fungi, viruses and parasites. NO signaling directs a broad spectrum of processes, including the differentiation, proliferation, and apoptosis of immune cells. When secreted by activated immune cells, NO diffuses across cellular membranes and exacts nitrosative and oxidative damage on invading pathogens. These observations led to the development of NO delivery systems that can harness the antimicrobial properties of this evanescent gas. The innate microbicidal properties of NO, as well as the antimicrobial activity of the various NO delivery systems, are reviewed.

Original languageEnglish (US)
Pages (from-to)8
Number of pages1
JournalVirulence
Volume3
Issue number3
StatePublished - May 2012

Fingerprint

Anti-Infective Agents
Nitric Oxide
Therapeutics
Gases
Parasites
Fungi
Apoptosis
Viruses
Bacteria
Membranes

Keywords

  • Antibiotic
  • Antimicrobial
  • Nanotechnology
  • Nitric oxide

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology
  • Parasitology
  • Immunology
  • Microbiology (medical)

Cite this

Schairer, D. O., Chouake, J. S., Nosanchuk, J. D., & Friedman, A. J. (2012). The potential of nitric oxide releasing therapies as antimicrobial agents. Virulence, 3(3), 8.

The potential of nitric oxide releasing therapies as antimicrobial agents. / Schairer, David O.; Chouake, Jason S.; Nosanchuk, Joshua D.; Friedman, Adam J.

In: Virulence, Vol. 3, No. 3, 05.2012, p. 8.

Research output: Contribution to journalArticle

Schairer, DO, Chouake, JS, Nosanchuk, JD & Friedman, AJ 2012, 'The potential of nitric oxide releasing therapies as antimicrobial agents', Virulence, vol. 3, no. 3, pp. 8.
Schairer, David O. ; Chouake, Jason S. ; Nosanchuk, Joshua D. ; Friedman, Adam J. / The potential of nitric oxide releasing therapies as antimicrobial agents. In: Virulence. 2012 ; Vol. 3, No. 3. pp. 8.
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