The pineapple eye Gene Is Required for Survival of Drosophila Imaginal Disc Cells

Wei Shi, Argyrios Stampas, Cynthia Zapata, Nicholas E. Baker

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Each ommatidium of the Drosophila eye is constructed by precisely 19 specified precursor cells, generated in part during a second mitotic wave of cell divisions that overlaps early stages of ommatidial cell specification. Homozygotes for the pineapple eye mutation lack sufficient precursor cells due to apoptosis during the period of fate specification. In addition development is delayed by apoptosis during earlier imaginal disc growth. Null alleles are recessive lethal and allelic to l(2)31Ek; heteroallelic combinations can show developmental delay, abnormal eye development, and reduced fertility. Mosaic clones autonomously show extensive cell death. The pineapple eye gene was identified and predicted to encode a novel 582-amino-acid protein. The protein contains a novel, cysteine-rich domain of 270 amino acids also found in predicted proteins of unknown function from other animals.

Original languageEnglish (US)
Pages (from-to)1869-1879
Number of pages11
JournalGenetics
Volume165
Issue number4
StatePublished - Dec 2003

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Ananas
Imaginal Discs
Drosophila
Genes
Lethal Genes
Apoptosis
Amino Acids
Proteins
Homozygote
Cell Division
Cysteine
Fertility
Cell Death
Clone Cells
Mutation
Growth

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

The pineapple eye Gene Is Required for Survival of Drosophila Imaginal Disc Cells. / Shi, Wei; Stampas, Argyrios; Zapata, Cynthia; Baker, Nicholas E.

In: Genetics, Vol. 165, No. 4, 12.2003, p. 1869-1879.

Research output: Contribution to journalArticle

Shi, W, Stampas, A, Zapata, C & Baker, NE 2003, 'The pineapple eye Gene Is Required for Survival of Drosophila Imaginal Disc Cells', Genetics, vol. 165, no. 4, pp. 1869-1879.
Shi, Wei ; Stampas, Argyrios ; Zapata, Cynthia ; Baker, Nicholas E. / The pineapple eye Gene Is Required for Survival of Drosophila Imaginal Disc Cells. In: Genetics. 2003 ; Vol. 165, No. 4. pp. 1869-1879.
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