The Patterns of Relapse in Osteosarcoma: The Memorial Sloan-Kettering Experience

Susan N. Chi, Laurie S. Conklin, Jing Qin, Paul A. Meyers, Andrew G. Huvos, John H. Healey, Richard Gorlick

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background. With the introduction of intensive high-dose chemotherapy for the treatment of osteosarcoma, changes in the pattern of metastases observed at relapse have been reported. To further investigate this hypothesis, the relapse patterns among groups receiving chemotherapy regimens of variable intensity at Memorial Sloan-Kettering Cancer Center were analyzed. Procedure. All patients treated with the protocols T4, T5, T7, T10, and T12 were included. Patients were divided into two groups, one including those patients treated with less intense therapy (T4, T5, and T7) and the other, those treated with current regimens (T10 and T12). Results. Of the 25 patients who relapsed on the earlier protocols, 76% relapsed to the lungs, 8% had local recurrences, and 16% distant metastases to the bone. The median time to first relapse was 12 months. Of the 69 patients who relapsed on the T10 and T12 protocols, 75% relapsed in the lungs, 9% had local recurrences, and 16% distant bone metastases. The median time to first relapse was 17 months. There was no statistically significant difference in the timing of relapse between the two groups studied, although a longer median time to relapse was observed for patients treated on the later protocols. The range of time to relapse was also wider in the later protocols. Conclusions. These data do not support the hypothesis that patterns of relapse are changing with alterations in osteosarcoma treatment. This limited single institutional experience can be explored further in the context of a multi-institutional effort.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalPediatric Blood and Cancer
Volume42
Issue number1
StatePublished - Jan 2004
Externally publishedYes

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Osteosarcoma
Recurrence
Neoplasm Metastasis
Bone and Bones
Drug Therapy
Lung
Therapeutics

Keywords

  • Adjuvant chemotherapy
  • Childhood cancer
  • Osteosarcoma
  • Relapse patterns

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Chi, S. N., Conklin, L. S., Qin, J., Meyers, P. A., Huvos, A. G., Healey, J. H., & Gorlick, R. (2004). The Patterns of Relapse in Osteosarcoma: The Memorial Sloan-Kettering Experience. Pediatric Blood and Cancer, 42(1), 46-51.

The Patterns of Relapse in Osteosarcoma : The Memorial Sloan-Kettering Experience. / Chi, Susan N.; Conklin, Laurie S.; Qin, Jing; Meyers, Paul A.; Huvos, Andrew G.; Healey, John H.; Gorlick, Richard.

In: Pediatric Blood and Cancer, Vol. 42, No. 1, 01.2004, p. 46-51.

Research output: Contribution to journalArticle

Chi, SN, Conklin, LS, Qin, J, Meyers, PA, Huvos, AG, Healey, JH & Gorlick, R 2004, 'The Patterns of Relapse in Osteosarcoma: The Memorial Sloan-Kettering Experience', Pediatric Blood and Cancer, vol. 42, no. 1, pp. 46-51.
Chi SN, Conklin LS, Qin J, Meyers PA, Huvos AG, Healey JH et al. The Patterns of Relapse in Osteosarcoma: The Memorial Sloan-Kettering Experience. Pediatric Blood and Cancer. 2004 Jan;42(1):46-51.
Chi, Susan N. ; Conklin, Laurie S. ; Qin, Jing ; Meyers, Paul A. ; Huvos, Andrew G. ; Healey, John H. ; Gorlick, Richard. / The Patterns of Relapse in Osteosarcoma : The Memorial Sloan-Kettering Experience. In: Pediatric Blood and Cancer. 2004 ; Vol. 42, No. 1. pp. 46-51.
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