The pathological implications of protein glycation

M. Brownlee

Research output: Contribution to journalArticle

138 Scopus citations

Abstract

Hyperglycemia, the most obvious metabolic abnormality in diabetes, is the primary causal factor responsible for the development of diabetic microvascular complications. There is considerable evidence linking hyperglycemia with the accelerated formation of irreversible nonenzymatic advanced glycosylation end products (AGEs), which subsequently accumulate in vessel wall proteins. The development of long-term vascular complications associated with diabetes appears to be related to the accumulation of these AGEs. Compounds that inhibit the development of AGE formation prevent complications in animal models and, therefore, may prove useful in reducing chronic diabetes-related complications in patients.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalClinical and Investigative Medicine
Volume18
Issue number4
StatePublished - Dec 1 1995

Keywords

  • Extracellular matrix
  • Inhibitors
  • Receptors

ASJC Scopus subject areas

  • Medicine(all)

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