The oxygen affinity of sickle hemoglobin

Amgad Abdu, José Gómez-Márquez, Thomas K. Aldrich

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (SO2), even when oxygen partial pressure (PO2) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal. We hypothesized that in SCD, in vivoSO2 is normal when PO2 is normal. We retrospectively examined 50 blood gas and COoximetry samples from SCD patients and from controls matched for pH, PO2, and carboxyhemoglobin. Control data fell close to the Severinghaus curve, as did non-hypoxemic (SO2 > 92.5 %) SCD data. In contrast, hypoxemic (SO2 < 92.5 %) SCD data fell well below the standard curve. Thus, although SCD patients' oxygen affinity is low under hypoxic conditions, it is normal at normal arterial SO2. Therefore, a finding of abnormally low saturation demonstrates that PO2 is abnormally low. Given our previous finding that pulse oximetry faithfully reflects saturation in SCD, low pulse oximeter readings in SCD constitute reliable evidence of impaired gas exchange.

Original languageEnglish (US)
Pages (from-to)92-94
Number of pages3
JournalRespiratory Physiology and Neurobiology
Volume161
Issue number1
DOIs
StatePublished - Mar 20 2008

Fingerprint

Sickle Hemoglobin
Sickle Cell Anemia
Oxygen
Gases
Carboxyhemoglobin
Oxyhemoglobins
Oximetry
Partial Pressure
Pulse
Reading
Polymers

Keywords

  • Anemia
  • Blood
  • Blood gases
  • Hemoglobin
  • Pulse oximetry

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

The oxygen affinity of sickle hemoglobin. / Abdu, Amgad; Gómez-Márquez, José; Aldrich, Thomas K.

In: Respiratory Physiology and Neurobiology, Vol. 161, No. 1, 20.03.2008, p. 92-94.

Research output: Contribution to journalArticle

Abdu, A, Gómez-Márquez, J & Aldrich, TK 2008, 'The oxygen affinity of sickle hemoglobin', Respiratory Physiology and Neurobiology, vol. 161, no. 1, pp. 92-94. https://doi.org/10.1016/j.resp.2007.12.005
Abdu, Amgad ; Gómez-Márquez, José ; Aldrich, Thomas K. / The oxygen affinity of sickle hemoglobin. In: Respiratory Physiology and Neurobiology. 2008 ; Vol. 161, No. 1. pp. 92-94.
@article{47b529aa694f4d82b7a8f74261384ba4,
title = "The oxygen affinity of sickle hemoglobin",
abstract = "The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (SO2), even when oxygen partial pressure (PO2) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal. We hypothesized that in SCD, in vivoSO2 is normal when PO2 is normal. We retrospectively examined 50 blood gas and COoximetry samples from SCD patients and from controls matched for pH, PO2, and carboxyhemoglobin. Control data fell close to the Severinghaus curve, as did non-hypoxemic (SO2 > 92.5 {\%}) SCD data. In contrast, hypoxemic (SO2 < 92.5 {\%}) SCD data fell well below the standard curve. Thus, although SCD patients' oxygen affinity is low under hypoxic conditions, it is normal at normal arterial SO2. Therefore, a finding of abnormally low saturation demonstrates that PO2 is abnormally low. Given our previous finding that pulse oximetry faithfully reflects saturation in SCD, low pulse oximeter readings in SCD constitute reliable evidence of impaired gas exchange.",
keywords = "Anemia, Blood, Blood gases, Hemoglobin, Pulse oximetry",
author = "Amgad Abdu and Jos{\'e} G{\'o}mez-M{\'a}rquez and Aldrich, {Thomas K.}",
year = "2008",
month = "3",
day = "20",
doi = "10.1016/j.resp.2007.12.005",
language = "English (US)",
volume = "161",
pages = "92--94",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - The oxygen affinity of sickle hemoglobin

AU - Abdu, Amgad

AU - Gómez-Márquez, José

AU - Aldrich, Thomas K.

PY - 2008/3/20

Y1 - 2008/3/20

N2 - The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (SO2), even when oxygen partial pressure (PO2) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal. We hypothesized that in SCD, in vivoSO2 is normal when PO2 is normal. We retrospectively examined 50 blood gas and COoximetry samples from SCD patients and from controls matched for pH, PO2, and carboxyhemoglobin. Control data fell close to the Severinghaus curve, as did non-hypoxemic (SO2 > 92.5 %) SCD data. In contrast, hypoxemic (SO2 < 92.5 %) SCD data fell well below the standard curve. Thus, although SCD patients' oxygen affinity is low under hypoxic conditions, it is normal at normal arterial SO2. Therefore, a finding of abnormally low saturation demonstrates that PO2 is abnormally low. Given our previous finding that pulse oximetry faithfully reflects saturation in SCD, low pulse oximeter readings in SCD constitute reliable evidence of impaired gas exchange.

AB - The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (SO2), even when oxygen partial pressure (PO2) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal. We hypothesized that in SCD, in vivoSO2 is normal when PO2 is normal. We retrospectively examined 50 blood gas and COoximetry samples from SCD patients and from controls matched for pH, PO2, and carboxyhemoglobin. Control data fell close to the Severinghaus curve, as did non-hypoxemic (SO2 > 92.5 %) SCD data. In contrast, hypoxemic (SO2 < 92.5 %) SCD data fell well below the standard curve. Thus, although SCD patients' oxygen affinity is low under hypoxic conditions, it is normal at normal arterial SO2. Therefore, a finding of abnormally low saturation demonstrates that PO2 is abnormally low. Given our previous finding that pulse oximetry faithfully reflects saturation in SCD, low pulse oximeter readings in SCD constitute reliable evidence of impaired gas exchange.

KW - Anemia

KW - Blood

KW - Blood gases

KW - Hemoglobin

KW - Pulse oximetry

UR - http://www.scopus.com/inward/record.url?scp=40049089432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40049089432&partnerID=8YFLogxK

U2 - 10.1016/j.resp.2007.12.005

DO - 10.1016/j.resp.2007.12.005

M3 - Article

VL - 161

SP - 92

EP - 94

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 1

ER -