The oxidation-reduction potential of copper-bleomycin

Dean L. Melnyk; Susan Band Horwitz; Jack Peisach

doi:10.1016/S0020-1693(00)81184-6

The oxidation-reduction potential of copper-bleomycin

Dean L. Melnyk, Susan Band Horwitz, Jack Peisach

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The oxidation-reduction potential of Cu(II)-bleomycin was measured at 25 °C, pH 7.0. With dithionite as reductant, the potential was -105 ± 9 mV with an n value near unity. With cysteine as reductant, the potential was -49 ± 10 mV, with an n value substantially greater than unity. The potentials are within a range that would allow the reduction of Cu(II)-bleomycin to take place in a cell.

Original language	English (US)
Pages (from-to)	75-78
Number of pages	4
Journal	Inorganica Chimica Acta
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/S0020-1693(00)81184-6
State	Published - Sep 1987

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/S0020-1693(00)81184-6

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title = "The oxidation-reduction potential of copper-bleomycin",

abstract = "The oxidation-reduction potential of Cu(II)-bleomycin was measured at 25 °C, pH 7.0. With dithionite as reductant, the potential was -105 ± 9 mV with an n value near unity. With cysteine as reductant, the potential was -49 ± 10 mV, with an n value substantially greater than unity. The potentials are within a range that would allow the reduction of Cu(II)-bleomycin to take place in a cell.",

author = "Melnyk, {Dean L.} and {Band Horwitz}, Susan and Jack Peisach",

note = "Funding Information: This work was supported by NIH grants HL-13399 (J.P.) and CA-39821 and GM-34555 (S.B.H), American Cancer Society grant CH-86 (S.B.H.) and the Rose C. Falkenstein Chair in Cancer Research (S.B.H.).",

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AU - Melnyk, Dean L.

AU - Band Horwitz, Susan

AU - Peisach, Jack

N1 - Funding Information: This work was supported by NIH grants HL-13399 (J.P.) and CA-39821 and GM-34555 (S.B.H), American Cancer Society grant CH-86 (S.B.H.) and the Rose C. Falkenstein Chair in Cancer Research (S.B.H.).

PY - 1987/9

Y1 - 1987/9

N2 - The oxidation-reduction potential of Cu(II)-bleomycin was measured at 25 °C, pH 7.0. With dithionite as reductant, the potential was -105 ± 9 mV with an n value near unity. With cysteine as reductant, the potential was -49 ± 10 mV, with an n value substantially greater than unity. The potentials are within a range that would allow the reduction of Cu(II)-bleomycin to take place in a cell.

AB - The oxidation-reduction potential of Cu(II)-bleomycin was measured at 25 °C, pH 7.0. With dithionite as reductant, the potential was -105 ± 9 mV with an n value near unity. With cysteine as reductant, the potential was -49 ± 10 mV, with an n value substantially greater than unity. The potentials are within a range that would allow the reduction of Cu(II)-bleomycin to take place in a cell.

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The oxidation-reduction potential of copper-bleomycin

Abstract

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