The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Viviana I. Pérez; Holly Van Remmen; Alex Bokov; Charles J. Epstein; Jan Vijg; Arlan Richardson

doi:10.1111/j.1474-9726.2008.00449.x

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Viviana I. Pérez, Holly Van Remmen, Alex Bokov, Charles J. Epstein, Jan Vijg, Arlan Richardson

Genetics

Research output: Contribution to journal › Article › peer-review

270 Scopus citations

Abstract

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

Original language	English (US)
Pages (from-to)	73-75
Number of pages	3
Journal	Aging cell
Volume	8
Issue number	1
DOIs	https://doi.org/10.1111/j.1474-9726.2008.00449.x
State	Published - 2009

Keywords

Aging
Antioxidant enzymes
Transgenic and knockout mice

ASJC Scopus subject areas

Aging
Cell Biology

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10.1111/j.1474-9726.2008.00449.x

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AU - Van Remmen, Holly

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AU - Epstein, Charles J.

AU - Vijg, Jan

AU - Richardson, Arlan

PY - 2009

Y1 - 2009

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AB - We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

KW - Aging

KW - Antioxidant enzymes

KW - Transgenic and knockout mice

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Abstract

Keywords

ASJC Scopus subject areas

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