The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Viviana I. Pérez, Holly Van Remmen, Alex Bokov, Charles J. Epstein, Jan Vijg, Arlan Richardson

Research output: Contribution to journalArticle

216 Scopus citations


We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

Original languageEnglish (US)
Pages (from-to)73-75
Number of pages3
JournalAging cell
Issue number1
StatePublished - Feb 4 2009



  • Aging
  • Antioxidant enzymes
  • Transgenic and knockout mice

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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