The origin and development of nonlymphoid tissue CD103+ DCs

Florent Ginhoux, Kang Liu, Julie Helft, Milena Bogunovic, Melanie Greter, Daigo Hashimoto, Jeremy Price, Na Yin, Jonathan Bromberg, Sergio A. Lira, E. Richard Stanley, Michel Nussenzweig, Miriam Merad

Research output: Contribution to journalArticle

474 Citations (Scopus)

Abstract

CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103+ DCs are related to lymphoid organ CD8+ DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103+ DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c +MHCII+ cells in tissues, which is CD103-CD11b +, is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103+ DCs and lymphoid organ CD8 + DCs derive from the same precursor and follow a related differentiation program.

Original languageEnglish (US)
Pages (from-to)3115-3130
Number of pages16
JournalJournal of Experimental Medicine
Volume206
Issue number13
DOIs
StatePublished - Dec 21 2009

Fingerprint

Dendritic Cells
Mucous Membrane
fms-Like Tyrosine Kinase 3
Cross-Priming
Proteins
DNA
Population
Antigens

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., ... Merad, M. (2009). The origin and development of nonlymphoid tissue CD103+ DCs. Journal of Experimental Medicine, 206(13), 3115-3130. https://doi.org/10.1084/jem.20091756

The origin and development of nonlymphoid tissue CD103+ DCs. / Ginhoux, Florent; Liu, Kang; Helft, Julie; Bogunovic, Milena; Greter, Melanie; Hashimoto, Daigo; Price, Jeremy; Yin, Na; Bromberg, Jonathan; Lira, Sergio A.; Stanley, E. Richard; Nussenzweig, Michel; Merad, Miriam.

In: Journal of Experimental Medicine, Vol. 206, No. 13, 21.12.2009, p. 3115-3130.

Research output: Contribution to journalArticle

Ginhoux, F, Liu, K, Helft, J, Bogunovic, M, Greter, M, Hashimoto, D, Price, J, Yin, N, Bromberg, J, Lira, SA, Stanley, ER, Nussenzweig, M & Merad, M 2009, 'The origin and development of nonlymphoid tissue CD103+ DCs', Journal of Experimental Medicine, vol. 206, no. 13, pp. 3115-3130. https://doi.org/10.1084/jem.20091756
Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D et al. The origin and development of nonlymphoid tissue CD103+ DCs. Journal of Experimental Medicine. 2009 Dec 21;206(13):3115-3130. https://doi.org/10.1084/jem.20091756
Ginhoux, Florent ; Liu, Kang ; Helft, Julie ; Bogunovic, Milena ; Greter, Melanie ; Hashimoto, Daigo ; Price, Jeremy ; Yin, Na ; Bromberg, Jonathan ; Lira, Sergio A. ; Stanley, E. Richard ; Nussenzweig, Michel ; Merad, Miriam. / The origin and development of nonlymphoid tissue CD103+ DCs. In: Journal of Experimental Medicine. 2009 ; Vol. 206, No. 13. pp. 3115-3130.
@article{9e378340bda5434c8b002f193716955c,
title = "The origin and development of nonlymphoid tissue CD103+ DCs",
abstract = "CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103+ DCs are related to lymphoid organ CD8+ DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103+ DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c +MHCII+ cells in tissues, which is CD103-CD11b +, is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103+ DCs and lymphoid organ CD8 + DCs derive from the same precursor and follow a related differentiation program.",
author = "Florent Ginhoux and Kang Liu and Julie Helft and Milena Bogunovic and Melanie Greter and Daigo Hashimoto and Jeremy Price and Na Yin and Jonathan Bromberg and Lira, {Sergio A.} and Stanley, {E. Richard} and Michel Nussenzweig and Miriam Merad",
year = "2009",
month = "12",
day = "21",
doi = "10.1084/jem.20091756",
language = "English (US)",
volume = "206",
pages = "3115--3130",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "13",

}

TY - JOUR

T1 - The origin and development of nonlymphoid tissue CD103+ DCs

AU - Ginhoux, Florent

AU - Liu, Kang

AU - Helft, Julie

AU - Bogunovic, Milena

AU - Greter, Melanie

AU - Hashimoto, Daigo

AU - Price, Jeremy

AU - Yin, Na

AU - Bromberg, Jonathan

AU - Lira, Sergio A.

AU - Stanley, E. Richard

AU - Nussenzweig, Michel

AU - Merad, Miriam

PY - 2009/12/21

Y1 - 2009/12/21

N2 - CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103+ DCs are related to lymphoid organ CD8+ DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103+ DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c +MHCII+ cells in tissues, which is CD103-CD11b +, is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103+ DCs and lymphoid organ CD8 + DCs derive from the same precursor and follow a related differentiation program.

AB - CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103+ DCs are related to lymphoid organ CD8+ DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103+ DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c +MHCII+ cells in tissues, which is CD103-CD11b +, is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103+ DCs and lymphoid organ CD8 + DCs derive from the same precursor and follow a related differentiation program.

UR - http://www.scopus.com/inward/record.url?scp=73949101833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73949101833&partnerID=8YFLogxK

U2 - 10.1084/jem.20091756

DO - 10.1084/jem.20091756

M3 - Article

VL - 206

SP - 3115

EP - 3130

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 13

ER -