The optimal MR acquisition strategy for exponential decay constants estimation

Roman Fleysher, Lazar Fleysher, Oded Gonen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Estimating the relaxation constant of an exponentially decaying signal from experimental MR data is fundamental in diffusion tensor imaging, fractional anisotropy mapping, measurements of transverse relaxation rates and contrast agent uptake. The precision of such measurements depends on the choice of acquisition parameters made at the design stage of the experiments. In this report, χ2 fitting of multipoint data is used to demonstrate that the most efficient acquisition strategy is a two-point scheme. We also conjecture that the smallest coefficient of variation of the decay constant achievable in any N-point experiment is 3.6 times larger than that in the image intensity obtained by averaging N acquisitions with minimal exponential weighting.

Original languageEnglish (US)
Pages (from-to)433-435
Number of pages3
JournalMagnetic Resonance Imaging
Volume26
Issue number3
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Diffusion Tensor Imaging
Anisotropy
Contrast Media
acquisition
Diffusion tensor imaging
decay
Experiments
estimating
tensors
anisotropy
coefficients

Keywords

  • Diffusion, contrast agents, optimization methods
  • Exponential decay
  • T2

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

The optimal MR acquisition strategy for exponential decay constants estimation. / Fleysher, Roman; Fleysher, Lazar; Gonen, Oded.

In: Magnetic Resonance Imaging, Vol. 26, No. 3, 04.2008, p. 433-435.

Research output: Contribution to journalArticle

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