TY - JOUR
T1 - The nuclear bodies inside out
T2 - PML conquers the cytoplasm
AU - Carracedo, Arkaitz
AU - Ito, Keisuke
AU - Pandolfi, Pier Paolo
N1 - Funding Information:
We thank all members of the Pandolfi laboratory for comments and discussion. We apologize to those whose publication related to the discussed issues could not be cited due to space limitations. A.C. was supported by the Ramón y Cajal award from the Spanish Ministry of Education. K.I. was supported by a K99 NIH grant.
PY - 2011/6
Y1 - 2011/6
N2 - The promyelocytic leukemia (PML) protein is the core component of nuclear substructures that host more than 70 proteins, termed nuclear domains 10 or PML-nuclear bodies. PML was first identified as the gene participating in the translocation responsible for the pathogenesis of acute promyelocytic leukemia (APL). The notion that PML is a tumor suppressor gene was soon extrapolated from leukemia to solid tumors. The last decade has radically changed the view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions. Notably, one of the most recent and striking features uncovered is how PML regulates cellular homeostasis outside its original niche in the nucleus. These new findings open an exciting new area of research in extra-nuclear PML functions.
AB - The promyelocytic leukemia (PML) protein is the core component of nuclear substructures that host more than 70 proteins, termed nuclear domains 10 or PML-nuclear bodies. PML was first identified as the gene participating in the translocation responsible for the pathogenesis of acute promyelocytic leukemia (APL). The notion that PML is a tumor suppressor gene was soon extrapolated from leukemia to solid tumors. The last decade has radically changed the view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions. Notably, one of the most recent and striking features uncovered is how PML regulates cellular homeostasis outside its original niche in the nucleus. These new findings open an exciting new area of research in extra-nuclear PML functions.
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U2 - 10.1016/j.ceb.2011.03.011
DO - 10.1016/j.ceb.2011.03.011
M3 - Review article
C2 - 21501958
AN - SCOPUS:79957798908
SN - 0955-0674
VL - 23
SP - 360
EP - 366
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -