The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Lupus nephritis, a potentially devastating outcome of systemic lupus erythematosus (SLE), poses a real challenge in the management of SLE patients because of the difficulty in diagnosing its onset and identifying relapses before serious renal damage has ensued. Neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 has been implicated in the pathogenesis of several disease states in different organ systems, and especially in kidney diseases. Lipocalin-2 may play a protective role in the context of renal insults through the induction or prevention of apoptosis by an iron-transport dependent mechanism. Clinically, urinary Lipocalin-2 significantly correlates with measures of lupus nephritis disease activity, and may be an important and convenient marker for relapses.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalAutoimmunity Reviews
Volume7
Issue number3
DOIs
StatePublished - Jan 2008

Fingerprint

Lupus Nephritis
Matrix Metalloproteinase 9
Biomarkers
Systemic Lupus Erythematosus
Kidney
Recurrence
Kidney Diseases
Iron
Apoptosis
Lipocalin-2

Keywords

  • Biomarkers
  • Lipocalin-2
  • Lupus nephritis
  • Neutrophil gelatinase-B associated lipocalin
  • NGAL
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis. / Rubinstein, Tamar; Pitashny, Milena; Putterman, Chaim.

In: Autoimmunity Reviews, Vol. 7, No. 3, 01.2008, p. 229-234.

Research output: Contribution to journalArticle

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