TY - JOUR
T1 - The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis
AU - Rubinstein, Tamar
AU - Pitashny, Milena
AU - Putterman, Chaim
PY - 2008/1
Y1 - 2008/1
N2 - Lupus nephritis, a potentially devastating outcome of systemic lupus erythematosus (SLE), poses a real challenge in the management of SLE patients because of the difficulty in diagnosing its onset and identifying relapses before serious renal damage has ensued. Neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 has been implicated in the pathogenesis of several disease states in different organ systems, and especially in kidney diseases. Lipocalin-2 may play a protective role in the context of renal insults through the induction or prevention of apoptosis by an iron-transport dependent mechanism. Clinically, urinary Lipocalin-2 significantly correlates with measures of lupus nephritis disease activity, and may be an important and convenient marker for relapses.
AB - Lupus nephritis, a potentially devastating outcome of systemic lupus erythematosus (SLE), poses a real challenge in the management of SLE patients because of the difficulty in diagnosing its onset and identifying relapses before serious renal damage has ensued. Neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 has been implicated in the pathogenesis of several disease states in different organ systems, and especially in kidney diseases. Lipocalin-2 may play a protective role in the context of renal insults through the induction or prevention of apoptosis by an iron-transport dependent mechanism. Clinically, urinary Lipocalin-2 significantly correlates with measures of lupus nephritis disease activity, and may be an important and convenient marker for relapses.
KW - Biomarkers
KW - Lipocalin-2
KW - Lupus nephritis
KW - NGAL
KW - Neutrophil gelatinase-B associated lipocalin
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=37649022459&partnerID=8YFLogxK
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U2 - 10.1016/j.autrev.2007.11.013
DO - 10.1016/j.autrev.2007.11.013
M3 - Review article
C2 - 18190883
AN - SCOPUS:37649022459
SN - 1568-9972
VL - 7
SP - 229
EP - 234
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 3
ER -