TY - JOUR
T1 - The neuroscience of affiliation
T2 - Forging links between basic and clinical research on neuropeptides and social behavior
AU - A. Bartz, Jennifer
AU - Hollander, Eric
N1 - Funding Information:
Preparation of this article was supported by grants from the National Institute of Health 5 U54 MH066673-03 STAART Autism Centers of Excellence, Beatrice and Samuel A. Seaver Foundation, National Institute on Neurological Disorders and Stroke, National Institute on Drug Abuse, and the Orphan Products Division of the Food and Drug Administration. We gratefully acknowledge Evdokia Anagnostou for comments on an earlier version of this article. Dr. Hollander is listed as an inventor on a patent for Treatment of Autism and Similar Disorders with Oxytocin.
PY - 2006/11
Y1 - 2006/11
N2 - Animal studies point to the role of two neuropeptides-oxytocin and vasopressin-in the regulation of affiliative behaviors including mating, pair-bond formation, maternal/parenting behavior, and attachment. These findings may have important implications for understanding and treating clinical disorders marked by social deficits and/or disrupted attachment. This review focuses on advances made to date in the effort to forge links between basic and clinical research in the area of neuropeptides and social behavior. The literature on oxytocin and its involvement in stress response, affiliation, and prosocial behavior is reviewed, and the implications of these findings for such disorders as autism as well as other social and stress-related disorders including social phobia, post-traumatic stress disorder, and some personality disorders are considered. Finally, unresolved issues and directions for future research are discussed.
AB - Animal studies point to the role of two neuropeptides-oxytocin and vasopressin-in the regulation of affiliative behaviors including mating, pair-bond formation, maternal/parenting behavior, and attachment. These findings may have important implications for understanding and treating clinical disorders marked by social deficits and/or disrupted attachment. This review focuses on advances made to date in the effort to forge links between basic and clinical research in the area of neuropeptides and social behavior. The literature on oxytocin and its involvement in stress response, affiliation, and prosocial behavior is reviewed, and the implications of these findings for such disorders as autism as well as other social and stress-related disorders including social phobia, post-traumatic stress disorder, and some personality disorders are considered. Finally, unresolved issues and directions for future research are discussed.
KW - Autism
KW - Neuropeptides
KW - Oxytocin
KW - Social behavior
KW - Translational research
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U2 - 10.1016/j.yhbeh.2006.06.018
DO - 10.1016/j.yhbeh.2006.06.018
M3 - Article
C2 - 16884725
AN - SCOPUS:33748093784
SN - 0018-506X
VL - 50
SP - 518
EP - 528
JO - Hormones and Behavior
JF - Hormones and Behavior
IS - 4
ER -