The Neuroendocrine Challenge Paradigm in Headache Research

M. L. Gordon, R. B. Lipton, S. L. Brown, HM Van Praag

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The neuroendocrine challenge paradigm provides a “window” on central neurotransmitter function in vivo. This strategy is based on the premise that the sensitivity of certain central receptors can be inferred from the magnitude of the hormonal response to specific pharmacologic probes. For example, the serotonin (5HT) receptor agonist m-chlorophenylpiperazine (m-CPP) stimulates the release of cortisol and prolactin and induces migraine-like headaches. We have previously reported that the headache and cortisol responses to m-CPP are highly correlated, which may implicate a disturbance in central serotonergic neurotransmission in the pathogenesis of migraine. As pharmacologic probes with greater specificity for 5HT receptor subtypes become available, we may be able to elucidate these mechanisms with greater precision. The neuroendocrine challenge methodology is also applicable to the study of other neurotransmitter systems and other headache disorders.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
Issue number4
StatePublished - Aug 1995


  • Hydrocortisone
  • m-chlorophenylpiperazine
  • migraine
  • prolactin
  • serotonin

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'The Neuroendocrine Challenge Paradigm in Headache Research'. Together they form a unique fingerprint.

Cite this