The neurobiological effects of repetitive head impacts in collision sports

Liane E. Hunter; Craig A. Branch; Michael L. Lipton

doi:10.1016/j.nbd.2018.06.016

The neurobiological effects of repetitive head impacts in collision sports

Liane E. Hunter, Craig A. Branch, Michael L. Lipton

Radiology

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment, it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.

Original language	English (US)
Pages (from-to)	122-126
Number of pages	5
Journal	Neurobiology of Disease
Volume	123
DOIs	https://doi.org/10.1016/j.nbd.2018.06.016
State	Published - Mar 2019

Keywords

Collision sports
Mild traumatic brain injury
Repetitive head injuries

ASJC Scopus subject areas

Neurology

Access to Document

10.1016/j.nbd.2018.06.016

Cite this

@article{d20d55f8da7e419c8520f200f53d2a32,

title = "The neurobiological effects of repetitive head impacts in collision sports",

abstract = "It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment, it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.",

keywords = "Collision sports, Mild traumatic brain injury, Repetitive head injuries",

author = "Hunter, {Liane E.} and Branch, {Craig A.} and Lipton, {Michael L.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = mar,

doi = "10.1016/j.nbd.2018.06.016",

language = "English (US)",

volume = "123",

pages = "122--126",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - The neurobiological effects of repetitive head impacts in collision sports

AU - Hunter, Liane E.

AU - Branch, Craig A.

AU - Lipton, Michael L.

PY - 2019/3

Y1 - 2019/3

N2 - It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment, it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.

AB - It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment, it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.

KW - Collision sports

KW - Mild traumatic brain injury

KW - Repetitive head injuries

UR - http://www.scopus.com/inward/record.url?scp=85049334787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049334787&partnerID=8YFLogxK

U2 - 10.1016/j.nbd.2018.06.016

DO - 10.1016/j.nbd.2018.06.016

M3 - Review article

C2 - 29936233

AN - SCOPUS:85049334787

SN - 0969-9961

VL - 123

SP - 122

EP - 126

JO - Neurobiology of Disease

JF - Neurobiology of Disease

ER -

The neurobiological effects of repetitive head impacts in collision sports

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this