The advent of highly effective antipanic medications with specific serotonin reuptake inhibition as a mechanism of action has prompted the need for new pathophysiological models of panic disorder. The authors attempt an integration of the emerging basic science literature regarding the neuroanatomy and physiology of the mammalian central serotonin nervous system, its influence an neural substrates that underlie fear and defense responses, and the clinical literature pertaining to serotonin-related abnormalities in panic disorder. A neuroanatomical model for the potential sites of action of the specific serotonin reuptake inhibitors in panic disorder is proposed.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Neuropsychiatry and Clinical Neurosciences|
|State||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health