The neural dynamics of somatosensory processing and adaptation across childhood: A high-density electrical mapping study

Neha Uppal, John J. Foxe, John S. Butler, Frantzy Acluche, Sophie Molholm

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. Based on the idea that neurodevelopmental changes in somatosensory processing and/or changes in sensory adaptation might underlie developmental differences in somatosensory reactivity, high-density electroencephalography was used to examine how the nervous system responds and adapts to repeated vibrotactile stimulation over childhood. Participants aged 6-18 yr old were presented with 50-ms vibrotactile stimuli to the right wrist over the median nerve at 5 blocked interstimulus intervals (ranging from ~7 to ~1 stimulus per second). Somatosensory evoked potentials (SEPs) revealed three major phases of activation within the first 200 ms, with scalp topographies suggestive of neural generators in contralateral somatosensory cortex. Although overall SEPs were highly similar for younger, middle, and older age groups (6.1-9.8, 10.0 -12.9, and 13.0 -17.8 yr old), there were significant age-related amplitude differences in initial and later phases of the SEP. In contrast, robust adaptation effects for fast vs. slow presentation rates were observed that did not differ as a function of age. A greater amplitude response in the later portion of the SEP was observed for the youngest group and may be related to developmental changes in responsivity to somatosensory stimuli. These data suggest the protracted development of the somatosensory system over childhood, whereas adaptation, as assayed in this study, is largely in place by ~7 yr of age.

Original languageEnglish (US)
Pages (from-to)1605-1619
Number of pages15
JournalJournal of Neurophysiology
Volume115
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Somatosensory Evoked Potentials
Clothing
Somatosensory Cortex
Median Nerve
Scalp
Wrist
Nervous System
Electroencephalography
Age Groups

Keywords

  • Development
  • ERP
  • Gating
  • Habituation
  • Tactile

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Medicine(all)

Cite this

The neural dynamics of somatosensory processing and adaptation across childhood : A high-density electrical mapping study. / Uppal, Neha; Foxe, John J.; Butler, John S.; Acluche, Frantzy; Molholm, Sophie.

In: Journal of Neurophysiology, Vol. 115, No. 3, 01.03.2016, p. 1605-1619.

Research output: Contribution to journalArticle

Uppal, Neha ; Foxe, John J. ; Butler, John S. ; Acluche, Frantzy ; Molholm, Sophie. / The neural dynamics of somatosensory processing and adaptation across childhood : A high-density electrical mapping study. In: Journal of Neurophysiology. 2016 ; Vol. 115, No. 3. pp. 1605-1619.
@article{340069ed9a30499787cde59a664815a8,
title = "The neural dynamics of somatosensory processing and adaptation across childhood: A high-density electrical mapping study",
abstract = "Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. Based on the idea that neurodevelopmental changes in somatosensory processing and/or changes in sensory adaptation might underlie developmental differences in somatosensory reactivity, high-density electroencephalography was used to examine how the nervous system responds and adapts to repeated vibrotactile stimulation over childhood. Participants aged 6-18 yr old were presented with 50-ms vibrotactile stimuli to the right wrist over the median nerve at 5 blocked interstimulus intervals (ranging from ~7 to ~1 stimulus per second). Somatosensory evoked potentials (SEPs) revealed three major phases of activation within the first 200 ms, with scalp topographies suggestive of neural generators in contralateral somatosensory cortex. Although overall SEPs were highly similar for younger, middle, and older age groups (6.1-9.8, 10.0 -12.9, and 13.0 -17.8 yr old), there were significant age-related amplitude differences in initial and later phases of the SEP. In contrast, robust adaptation effects for fast vs. slow presentation rates were observed that did not differ as a function of age. A greater amplitude response in the later portion of the SEP was observed for the youngest group and may be related to developmental changes in responsivity to somatosensory stimuli. These data suggest the protracted development of the somatosensory system over childhood, whereas adaptation, as assayed in this study, is largely in place by ~7 yr of age.",
keywords = "Development, ERP, Gating, Habituation, Tactile",
author = "Neha Uppal and Foxe, {John J.} and Butler, {John S.} and Frantzy Acluche and Sophie Molholm",
year = "2016",
month = "3",
day = "1",
doi = "10.1152/jn.01059.2015",
language = "English (US)",
volume = "115",
pages = "1605--1619",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - The neural dynamics of somatosensory processing and adaptation across childhood

T2 - A high-density electrical mapping study

AU - Uppal, Neha

AU - Foxe, John J.

AU - Butler, John S.

AU - Acluche, Frantzy

AU - Molholm, Sophie

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. Based on the idea that neurodevelopmental changes in somatosensory processing and/or changes in sensory adaptation might underlie developmental differences in somatosensory reactivity, high-density electroencephalography was used to examine how the nervous system responds and adapts to repeated vibrotactile stimulation over childhood. Participants aged 6-18 yr old were presented with 50-ms vibrotactile stimuli to the right wrist over the median nerve at 5 blocked interstimulus intervals (ranging from ~7 to ~1 stimulus per second). Somatosensory evoked potentials (SEPs) revealed three major phases of activation within the first 200 ms, with scalp topographies suggestive of neural generators in contralateral somatosensory cortex. Although overall SEPs were highly similar for younger, middle, and older age groups (6.1-9.8, 10.0 -12.9, and 13.0 -17.8 yr old), there were significant age-related amplitude differences in initial and later phases of the SEP. In contrast, robust adaptation effects for fast vs. slow presentation rates were observed that did not differ as a function of age. A greater amplitude response in the later portion of the SEP was observed for the youngest group and may be related to developmental changes in responsivity to somatosensory stimuli. These data suggest the protracted development of the somatosensory system over childhood, whereas adaptation, as assayed in this study, is largely in place by ~7 yr of age.

AB - Young children are often hyperreactive to somatosensory inputs hardly noticed by adults, as exemplified by irritation to seams or labels in clothing. The neurodevelopmental mechanisms underlying changes in sensory reactivity are not well understood. Based on the idea that neurodevelopmental changes in somatosensory processing and/or changes in sensory adaptation might underlie developmental differences in somatosensory reactivity, high-density electroencephalography was used to examine how the nervous system responds and adapts to repeated vibrotactile stimulation over childhood. Participants aged 6-18 yr old were presented with 50-ms vibrotactile stimuli to the right wrist over the median nerve at 5 blocked interstimulus intervals (ranging from ~7 to ~1 stimulus per second). Somatosensory evoked potentials (SEPs) revealed three major phases of activation within the first 200 ms, with scalp topographies suggestive of neural generators in contralateral somatosensory cortex. Although overall SEPs were highly similar for younger, middle, and older age groups (6.1-9.8, 10.0 -12.9, and 13.0 -17.8 yr old), there were significant age-related amplitude differences in initial and later phases of the SEP. In contrast, robust adaptation effects for fast vs. slow presentation rates were observed that did not differ as a function of age. A greater amplitude response in the later portion of the SEP was observed for the youngest group and may be related to developmental changes in responsivity to somatosensory stimuli. These data suggest the protracted development of the somatosensory system over childhood, whereas adaptation, as assayed in this study, is largely in place by ~7 yr of age.

KW - Development

KW - ERP

KW - Gating

KW - Habituation

KW - Tactile

UR - http://www.scopus.com/inward/record.url?scp=84984794013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984794013&partnerID=8YFLogxK

U2 - 10.1152/jn.01059.2015

DO - 10.1152/jn.01059.2015

M3 - Article

C2 - 26763781

AN - SCOPUS:84984794013

VL - 115

SP - 1605

EP - 1619

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 3

ER -