The neural circuitry of pre-attentive auditory change-detection: An fMRI study of pitch and duration mismatch negativity generators

Sophie Molholm, Antigona Martinez, Walter Ritter, Daniel C. Javitt, John J. Foxe

Research output: Contribution to journalArticle

229 Citations (Scopus)

Abstract

Electrophysiological studies have revealed a pre-attentive change-detection system in the auditory modality. This system emits a signal termed the mismatch negativity (MMN) when any detectable change in a regular pattern of auditory stimulation occurs. The precise intracranial sources underlying MMN generation, and in particular whether these vary as a function of the acoustic feature that changes, is a matter of some debate. Using functional magnetic resonance imaging, we show that anatomically distinct networks of auditory cortices are activated as a function of the deviating acoustic feature - in this case, tone frequency and tone duration - strongly supporting the hypothesis that MMN generators in auditory cortex are feature dependent. We also detail regions of the frontal and parietal cortices activated by change-detection processes. These regions also show feature dependence and we hypothesize that they reflect recruitment of attention-switching mechanisms.

Original languageEnglish (US)
Pages (from-to)545-551
Number of pages7
JournalCerebral Cortex
Volume15
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Auditory Cortex
Acoustics
Magnetic Resonance Imaging
Acoustic Stimulation
Parietal Lobe
Frontal Lobe

Keywords

  • Auditory
  • Change-detection
  • fMRI
  • MMN
  • Pre-attentive

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The neural circuitry of pre-attentive auditory change-detection : An fMRI study of pitch and duration mismatch negativity generators. / Molholm, Sophie; Martinez, Antigona; Ritter, Walter; Javitt, Daniel C.; Foxe, John J.

In: Cerebral Cortex, Vol. 15, No. 5, 05.2005, p. 545-551.

Research output: Contribution to journalArticle

Molholm, Sophie ; Martinez, Antigona ; Ritter, Walter ; Javitt, Daniel C. ; Foxe, John J. / The neural circuitry of pre-attentive auditory change-detection : An fMRI study of pitch and duration mismatch negativity generators. In: Cerebral Cortex. 2005 ; Vol. 15, No. 5. pp. 545-551.
@article{25a033c78923404d982135fff2445e64,
title = "The neural circuitry of pre-attentive auditory change-detection: An fMRI study of pitch and duration mismatch negativity generators",
abstract = "Electrophysiological studies have revealed a pre-attentive change-detection system in the auditory modality. This system emits a signal termed the mismatch negativity (MMN) when any detectable change in a regular pattern of auditory stimulation occurs. The precise intracranial sources underlying MMN generation, and in particular whether these vary as a function of the acoustic feature that changes, is a matter of some debate. Using functional magnetic resonance imaging, we show that anatomically distinct networks of auditory cortices are activated as a function of the deviating acoustic feature - in this case, tone frequency and tone duration - strongly supporting the hypothesis that MMN generators in auditory cortex are feature dependent. We also detail regions of the frontal and parietal cortices activated by change-detection processes. These regions also show feature dependence and we hypothesize that they reflect recruitment of attention-switching mechanisms.",
keywords = "Auditory, Change-detection, fMRI, MMN, Pre-attentive",
author = "Sophie Molholm and Antigona Martinez and Walter Ritter and Javitt, {Daniel C.} and Foxe, {John J.}",
year = "2005",
month = "5",
doi = "10.1093/cercor/bhh155",
language = "English (US)",
volume = "15",
pages = "545--551",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - The neural circuitry of pre-attentive auditory change-detection

T2 - An fMRI study of pitch and duration mismatch negativity generators

AU - Molholm, Sophie

AU - Martinez, Antigona

AU - Ritter, Walter

AU - Javitt, Daniel C.

AU - Foxe, John J.

PY - 2005/5

Y1 - 2005/5

N2 - Electrophysiological studies have revealed a pre-attentive change-detection system in the auditory modality. This system emits a signal termed the mismatch negativity (MMN) when any detectable change in a regular pattern of auditory stimulation occurs. The precise intracranial sources underlying MMN generation, and in particular whether these vary as a function of the acoustic feature that changes, is a matter of some debate. Using functional magnetic resonance imaging, we show that anatomically distinct networks of auditory cortices are activated as a function of the deviating acoustic feature - in this case, tone frequency and tone duration - strongly supporting the hypothesis that MMN generators in auditory cortex are feature dependent. We also detail regions of the frontal and parietal cortices activated by change-detection processes. These regions also show feature dependence and we hypothesize that they reflect recruitment of attention-switching mechanisms.

AB - Electrophysiological studies have revealed a pre-attentive change-detection system in the auditory modality. This system emits a signal termed the mismatch negativity (MMN) when any detectable change in a regular pattern of auditory stimulation occurs. The precise intracranial sources underlying MMN generation, and in particular whether these vary as a function of the acoustic feature that changes, is a matter of some debate. Using functional magnetic resonance imaging, we show that anatomically distinct networks of auditory cortices are activated as a function of the deviating acoustic feature - in this case, tone frequency and tone duration - strongly supporting the hypothesis that MMN generators in auditory cortex are feature dependent. We also detail regions of the frontal and parietal cortices activated by change-detection processes. These regions also show feature dependence and we hypothesize that they reflect recruitment of attention-switching mechanisms.

KW - Auditory

KW - Change-detection

KW - fMRI

KW - MMN

KW - Pre-attentive

UR - http://www.scopus.com/inward/record.url?scp=17744392452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17744392452&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhh155

DO - 10.1093/cercor/bhh155

M3 - Article

C2 - 15342438

AN - SCOPUS:17744392452

VL - 15

SP - 545

EP - 551

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 5

ER -