TY - JOUR
T1 - The natural history of human papillomavirus infection and cervical intraepithelial neoplasia among young women in the Guanacaste cohort shortly after initiation of sexual life
AU - Rodriguez, Ana Cecilia
AU - Burk, Robert
AU - Herrero, Rolando
AU - Hildesheim, Allan
AU - Bratti, Concepcion
AU - Sherman, Mark E.
AU - Solomon, Diane
AU - Guillen, Diego
AU - Alfaro, Mario
AU - Viscidi, Raphael
AU - Morales, Jorge
AU - Hutchinson, Martha
AU - Wacholder, Sholom
AU - Schiffman, Mark
PY - 2007/7
Y1 - 2007/7
N2 - OBJECTIVE: Cross-sectional analyses of our 10,000-woman, population-based Guanacaste cohort suggest a lag of ≥10 years between the peak of human papillomavirus (HPV) infection and the later peak of cervical intraepithelial neoplasia grade 3 (CIN 3). We wanted to explore early HPV natural history and CIN 3 prospectively. STUDY DESIGN: As part of the Guanacaste cohort, we followed 206 initially virginal women aged 18 to 26 semiannually for a median of 3.6 years after initiation of sexual life. RESULTS: A total of 53.4% of women tested positive during the study for ≥1 HPV type. Very few infections persisted for >1 to 2 years. Three women had histologically confirmed CIN 3, of which 2 showed persistent HPV 16. The other had serologic evidence of HPV 31. CONCLUSIONS: HPV infection occurs frequently and clears rapidly in most young women initiating sexual intercourse. Persistent HPV 16 can cause early CIN 3. The peak age for CIN 3 will decline with the increased screening intensity and sensitivity typical of longitudinal studies.
AB - OBJECTIVE: Cross-sectional analyses of our 10,000-woman, population-based Guanacaste cohort suggest a lag of ≥10 years between the peak of human papillomavirus (HPV) infection and the later peak of cervical intraepithelial neoplasia grade 3 (CIN 3). We wanted to explore early HPV natural history and CIN 3 prospectively. STUDY DESIGN: As part of the Guanacaste cohort, we followed 206 initially virginal women aged 18 to 26 semiannually for a median of 3.6 years after initiation of sexual life. RESULTS: A total of 53.4% of women tested positive during the study for ≥1 HPV type. Very few infections persisted for >1 to 2 years. Three women had histologically confirmed CIN 3, of which 2 showed persistent HPV 16. The other had serologic evidence of HPV 31. CONCLUSIONS: HPV infection occurs frequently and clears rapidly in most young women initiating sexual intercourse. Persistent HPV 16 can cause early CIN 3. The peak age for CIN 3 will decline with the increased screening intensity and sensitivity typical of longitudinal studies.
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U2 - 10.1097/01.olq.0000251241.03088.a0
DO - 10.1097/01.olq.0000251241.03088.a0
M3 - Article
C2 - 17237737
AN - SCOPUS:34250793877
SN - 0148-5717
VL - 34
SP - 494
EP - 502
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
IS - 7
ER -