The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

Roberto Diaz, Daniel Ahn, Lluis Lopez-Barcons, Marcos Malumbres, Ignacio Perez De Castro, Jeffrey Lue, Neus Ferrer-Miralles, Ramon Mangues, Jerry Tsong, Roberto Garcia, Roman Perez-Soler, Angel Pellicer

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Abstract

ras proto-oncogenes have traditionally been associated with the regulation and promotion of cell growth. We have induced thymic lymphomas in N-ras-/- mice and in transgenic mice that overexpress wild-type N-ras and found that the lack of wild-type N-ras alleles favors the development of thymic lymphomas, whereas overexpression of wild-type N-ras protects against thymic lymphomagenesis in the presence or absence of its oncogene. To investigate the inhibitory role of wild-type N-ras in in vitro transformation, we introduced wild-type N-ras in N-ras-deficient tumor cells that lack ras activating mutations and found decreased growth in both low serum and soft agar. Taken together, our results indicate that wild-type N-ras has "tumor suppressor" activity, even in the absence of its oncogenic allele.

Original languageEnglish (US)
Pages (from-to)4514-4518
Number of pages5
JournalCancer Research
Volume62
Issue number15
StatePublished - Aug 1 2002

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ras Genes
Proto-Oncogenes
Oncogenes
Lymphoma
Alleles
Phenotype
Growth
Transgenic Mice
Agar
Neoplasms
Mutation
Serum
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Diaz, R., Ahn, D., Lopez-Barcons, L., Malumbres, M., De Castro, I. P., Lue, J., ... Pellicer, A. (2002). The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Research, 62(15), 4514-4518.

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. / Diaz, Roberto; Ahn, Daniel; Lopez-Barcons, Lluis; Malumbres, Marcos; De Castro, Ignacio Perez; Lue, Jeffrey; Ferrer-Miralles, Neus; Mangues, Ramon; Tsong, Jerry; Garcia, Roberto; Perez-Soler, Roman; Pellicer, Angel.

In: Cancer Research, Vol. 62, No. 15, 01.08.2002, p. 4514-4518.

Research output: Contribution to journalArticle

Diaz, R, Ahn, D, Lopez-Barcons, L, Malumbres, M, De Castro, IP, Lue, J, Ferrer-Miralles, N, Mangues, R, Tsong, J, Garcia, R, Perez-Soler, R & Pellicer, A 2002, 'The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene', Cancer Research, vol. 62, no. 15, pp. 4514-4518.
Diaz R, Ahn D, Lopez-Barcons L, Malumbres M, De Castro IP, Lue J et al. The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Research. 2002 Aug 1;62(15):4514-4518.
Diaz, Roberto ; Ahn, Daniel ; Lopez-Barcons, Lluis ; Malumbres, Marcos ; De Castro, Ignacio Perez ; Lue, Jeffrey ; Ferrer-Miralles, Neus ; Mangues, Ramon ; Tsong, Jerry ; Garcia, Roberto ; Perez-Soler, Roman ; Pellicer, Angel. / The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. In: Cancer Research. 2002 ; Vol. 62, No. 15. pp. 4514-4518.
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