The Mycobacterium tuberculosis capsule: A cell structure with key implications in pathogenesis

Rainer Kalscheuer, Ainhoa Palacios, Itxaso Anso, Javier Cifuente, Juan Anguita, William R. Jacobs, Marcelo E. Guerin, Rafael Prados-Rosales

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis (Mtb) capsule began more than 60 years ago, but the relatively recent development of mycobacterial genetics combined with improved chemical and immunological tools have revealed a more refined view of capsule molecular composition. A glycogen-like α-glucan is the major constituent of the capsule, with lower amounts of arabinomannan and mannan, proteins and lipids. The major Mtb capsular components mediate interactions with phagocytes that favor bacterial survival. Vaccination approaches targeting the mycobacterial capsule have proven successful in controlling bacterial replication. Although the Mtb capsule is composed of polysaccharides of relatively low complexity, the concept of antigenic variability associated with this structure has been suggested by some studies. Understanding how Mtb shapes its envelope during its life cycle is key to developing anti-infective strategies targeting this structure at the host–pathogen interface.

Original languageEnglish (US)
Pages (from-to)1995-2016
Number of pages22
JournalBiochemical Journal
Volume476
Issue number14
DOIs
StatePublished - Jul 18 2019

Fingerprint

Mycobacterium tuberculosis
Capsules
Bacterial Capsules
Mannans
Antigenic Variation
Glucans
Phagocytes
Life Cycle Stages
Glycogen
Polysaccharides
Life cycle
Vaccination
Lipids
Chemical analysis
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kalscheuer, R., Palacios, A., Anso, I., Cifuente, J., Anguita, J., Jacobs, W. R., ... Prados-Rosales, R. (2019). The Mycobacterium tuberculosis capsule: A cell structure with key implications in pathogenesis. Biochemical Journal, 476(14), 1995-2016. https://doi.org/10.1042/BCJ20190324

The Mycobacterium tuberculosis capsule : A cell structure with key implications in pathogenesis. / Kalscheuer, Rainer; Palacios, Ainhoa; Anso, Itxaso; Cifuente, Javier; Anguita, Juan; Jacobs, William R.; Guerin, Marcelo E.; Prados-Rosales, Rafael.

In: Biochemical Journal, Vol. 476, No. 14, 18.07.2019, p. 1995-2016.

Research output: Contribution to journalReview article

Kalscheuer, R, Palacios, A, Anso, I, Cifuente, J, Anguita, J, Jacobs, WR, Guerin, ME & Prados-Rosales, R 2019, 'The Mycobacterium tuberculosis capsule: A cell structure with key implications in pathogenesis', Biochemical Journal, vol. 476, no. 14, pp. 1995-2016. https://doi.org/10.1042/BCJ20190324
Kalscheuer, Rainer ; Palacios, Ainhoa ; Anso, Itxaso ; Cifuente, Javier ; Anguita, Juan ; Jacobs, William R. ; Guerin, Marcelo E. ; Prados-Rosales, Rafael. / The Mycobacterium tuberculosis capsule : A cell structure with key implications in pathogenesis. In: Biochemical Journal. 2019 ; Vol. 476, No. 14. pp. 1995-2016.
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