The molecular diversity of glycosaminoglycans shapes animal development

Hannes E. Buelow, Oliver Hobert

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked to a protein core, are components of the extracellular matrix of all multicellular organisms. Sugar moieties in GAGs are often extensively modified, which make these molecules enormously complex. We discuss here the role of PGs during animal development, emphasizing the in vivo significance of sugar modifications. We explore a model in which the modification patterns of GAG chains may provide a specific code that contributes to the correct development of a multicellular organism.

Original languageEnglish (US)
Pages (from-to)375-407
Number of pages33
JournalAnnual Review of Cell and Developmental Biology
Volume22
DOIs
StatePublished - 2006

Fingerprint

Glycosaminoglycans
Proteoglycans
Extracellular Matrix
Proteins

Keywords

  • Axon patterning
  • Chondroitin sulfate
  • Dermatan sulfate
  • Heparan sulfate
  • Keratan sulfate
  • Proteoglycans

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

The molecular diversity of glycosaminoglycans shapes animal development. / Buelow, Hannes E.; Hobert, Oliver.

In: Annual Review of Cell and Developmental Biology, Vol. 22, 2006, p. 375-407.

Research output: Contribution to journalArticle

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