The molecular characteristics of bladder cancer in young patients

Jurgen F. Linn, Isabell Sesterhenn, Fathollah K. Mostofi, Mark P. Schoenberg

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Purpose: The molecular characteristics of bladder cancer in children and young adults remain largely undefined. We sought to identify common molecular changes in bladder tumors in young patients using standard immunohistochemical and interphase cytogenetic methods. Materials and Methods: We retrospectively evaluated 73 bladder tumors removed from patients younger than 30 years for the p53 tumor suppressor gene product using immunohistochemical techniques and numerical aberrations of chromosomes 9, 17, X and Y. Results: Regardless of stage, immunohistochemical evidence of p53 gene product over expression was found in the majority of tumors studied. Numerical aberrations (monosomy) of chromosome 9 were rare. Aneuploidy of chromosome 17 was common, particularly in carcinoma in situ and invasive bladder cancer. Conclusions: These data suggest that immunohistochemical evidence of p53 gene product over expression is common in bladder cancer in young patients. Further prospective analysis of lesions in this population may help to establish a comprehensive molecular progression model for urothelial neoplasms.

Original languageEnglish (US)
Pages (from-to)1493-1496
Number of pages4
JournalJournal of Urology
Volume159
Issue number5
StatePublished - May 1998
Externally publishedYes

Fingerprint

Urinary Bladder Neoplasms
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 17
p53 Genes
Monosomy
Molecular Models
Interphase
Carcinoma in Situ
Aneuploidy
Tumor Suppressor Genes
Cytogenetics
Young Adult
Neoplasms
Population

Keywords

  • Bladder
  • Genes, suppressor, tumor
  • Genetics

ASJC Scopus subject areas

  • Urology

Cite this

Linn, J. F., Sesterhenn, I., Mostofi, F. K., & Schoenberg, M. P. (1998). The molecular characteristics of bladder cancer in young patients. Journal of Urology, 159(5), 1493-1496.

The molecular characteristics of bladder cancer in young patients. / Linn, Jurgen F.; Sesterhenn, Isabell; Mostofi, Fathollah K.; Schoenberg, Mark P.

In: Journal of Urology, Vol. 159, No. 5, 05.1998, p. 1493-1496.

Research output: Contribution to journalArticle

Linn, JF, Sesterhenn, I, Mostofi, FK & Schoenberg, MP 1998, 'The molecular characteristics of bladder cancer in young patients', Journal of Urology, vol. 159, no. 5, pp. 1493-1496.
Linn, Jurgen F. ; Sesterhenn, Isabell ; Mostofi, Fathollah K. ; Schoenberg, Mark P. / The molecular characteristics of bladder cancer in young patients. In: Journal of Urology. 1998 ; Vol. 159, No. 5. pp. 1493-1496.
@article{3931cf142ae54fa59f51fe2cae31a984,
title = "The molecular characteristics of bladder cancer in young patients",
abstract = "Purpose: The molecular characteristics of bladder cancer in children and young adults remain largely undefined. We sought to identify common molecular changes in bladder tumors in young patients using standard immunohistochemical and interphase cytogenetic methods. Materials and Methods: We retrospectively evaluated 73 bladder tumors removed from patients younger than 30 years for the p53 tumor suppressor gene product using immunohistochemical techniques and numerical aberrations of chromosomes 9, 17, X and Y. Results: Regardless of stage, immunohistochemical evidence of p53 gene product over expression was found in the majority of tumors studied. Numerical aberrations (monosomy) of chromosome 9 were rare. Aneuploidy of chromosome 17 was common, particularly in carcinoma in situ and invasive bladder cancer. Conclusions: These data suggest that immunohistochemical evidence of p53 gene product over expression is common in bladder cancer in young patients. Further prospective analysis of lesions in this population may help to establish a comprehensive molecular progression model for urothelial neoplasms.",
keywords = "Bladder, Genes, suppressor, tumor, Genetics",
author = "Linn, {Jurgen F.} and Isabell Sesterhenn and Mostofi, {Fathollah K.} and Schoenberg, {Mark P.}",
year = "1998",
month = "5",
language = "English (US)",
volume = "159",
pages = "1493--1496",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - The molecular characteristics of bladder cancer in young patients

AU - Linn, Jurgen F.

AU - Sesterhenn, Isabell

AU - Mostofi, Fathollah K.

AU - Schoenberg, Mark P.

PY - 1998/5

Y1 - 1998/5

N2 - Purpose: The molecular characteristics of bladder cancer in children and young adults remain largely undefined. We sought to identify common molecular changes in bladder tumors in young patients using standard immunohistochemical and interphase cytogenetic methods. Materials and Methods: We retrospectively evaluated 73 bladder tumors removed from patients younger than 30 years for the p53 tumor suppressor gene product using immunohistochemical techniques and numerical aberrations of chromosomes 9, 17, X and Y. Results: Regardless of stage, immunohistochemical evidence of p53 gene product over expression was found in the majority of tumors studied. Numerical aberrations (monosomy) of chromosome 9 were rare. Aneuploidy of chromosome 17 was common, particularly in carcinoma in situ and invasive bladder cancer. Conclusions: These data suggest that immunohistochemical evidence of p53 gene product over expression is common in bladder cancer in young patients. Further prospective analysis of lesions in this population may help to establish a comprehensive molecular progression model for urothelial neoplasms.

AB - Purpose: The molecular characteristics of bladder cancer in children and young adults remain largely undefined. We sought to identify common molecular changes in bladder tumors in young patients using standard immunohistochemical and interphase cytogenetic methods. Materials and Methods: We retrospectively evaluated 73 bladder tumors removed from patients younger than 30 years for the p53 tumor suppressor gene product using immunohistochemical techniques and numerical aberrations of chromosomes 9, 17, X and Y. Results: Regardless of stage, immunohistochemical evidence of p53 gene product over expression was found in the majority of tumors studied. Numerical aberrations (monosomy) of chromosome 9 were rare. Aneuploidy of chromosome 17 was common, particularly in carcinoma in situ and invasive bladder cancer. Conclusions: These data suggest that immunohistochemical evidence of p53 gene product over expression is common in bladder cancer in young patients. Further prospective analysis of lesions in this population may help to establish a comprehensive molecular progression model for urothelial neoplasms.

KW - Bladder

KW - Genes, suppressor, tumor

KW - Genetics

UR - http://www.scopus.com/inward/record.url?scp=0032459554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032459554&partnerID=8YFLogxK

M3 - Article

C2 - 9554340

AN - SCOPUS:0032459554

VL - 159

SP - 1493

EP - 1496

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 5

ER -