The molecular basis of anaphase A in animal cells

Uttama Rath, David J. Sharp

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The mechanisms that move chromatids poleward during anaphase A have fascinated researchers for decades. There is now growing evidence that this movement is tightly linked to the active depolymerization of both ends of kinetochore-associated microtubules, a mechanism we refer to as "Pacman-Flux." Contemporary data suggest that this is catalyzed by the integration of multiple enzymatic activities including (1) microtubule-end depoly-merases housed at the pole or kinetochore, (2) microtubule-severing enzymes used to uncap the ends of kinetochore-associated microtubules, and (3) molecular motors which drive tubulins towards the pole or into kinetochores.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalChromosome Research
Volume19
Issue number3
DOIs
StatePublished - Apr 2011

Fingerprint

Kinetochores
Anaphase
Microtubules
Chromatids
Tubulin
Research Personnel
Enzymes

Keywords

  • Anaphase A
  • Mitosis
  • Pacman
  • Poleward flux
  • Spindle

ASJC Scopus subject areas

  • Genetics

Cite this

The molecular basis of anaphase A in animal cells. / Rath, Uttama; Sharp, David J.

In: Chromosome Research, Vol. 19, No. 3, 04.2011, p. 423-432.

Research output: Contribution to journalArticle

Rath, Uttama ; Sharp, David J. / The molecular basis of anaphase A in animal cells. In: Chromosome Research. 2011 ; Vol. 19, No. 3. pp. 423-432.
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