The molecular basis of anaphase A in animal cells

Uttama Rath, David J. Sharp

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The mechanisms that move chromatids poleward during anaphase A have fascinated researchers for decades. There is now growing evidence that this movement is tightly linked to the active depolymerization of both ends of kinetochore-associated microtubules, a mechanism we refer to as "Pacman-Flux." Contemporary data suggest that this is catalyzed by the integration of multiple enzymatic activities including (1) microtubule-end depoly-merases housed at the pole or kinetochore, (2) microtubule-severing enzymes used to uncap the ends of kinetochore-associated microtubules, and (3) molecular motors which drive tubulins towards the pole or into kinetochores.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalChromosome Research
Volume19
Issue number3
DOIs
StatePublished - Apr 2011

Keywords

  • Anaphase A
  • Mitosis
  • Pacman
  • Poleward flux
  • Spindle

ASJC Scopus subject areas

  • Genetics

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