The modular structure of actin-regulatory proteins

Yoram A. Puius; Nicole M. Mahoney; Steven C. Almo

doi:10.1016/S0955-0674(98)80083-5

The modular structure of actin-regulatory proteins

Yoram A. Puius, Nicole M. Mahoney, Steven C. Almo

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The site-specific assembly and disassembly of these structures are directed by actin-regulatory proteins. This article reviews how structural studies are now defining the atomic details of small modular domains present in actin-regulatory proteins responsible for crosslinking, severing and capping of actin filaments, as well as for localization of actin filament assembly. These studies have identified three modular strategies for the design of proteins that regulate the actin cytoskeleton.

Original language	English (US)
Pages (from-to)	23-34
Number of pages	12
Journal	Current Opinion in Cell Biology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/S0955-0674(98)80083-5
State	Published - Feb 1998

ASJC Scopus subject areas

Cell Biology

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10.1016/S0955-0674(98)80083-5

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title = "The modular structure of actin-regulatory proteins",

abstract = "Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The site-specific assembly and disassembly of these structures are directed by actin-regulatory proteins. This article reviews how structural studies are now defining the atomic details of small modular domains present in actin-regulatory proteins responsible for crosslinking, severing and capping of actin filaments, as well as for localization of actin filament assembly. These studies have identified three modular strategies for the design of proteins that regulate the actin cytoskeleton.",

author = "Puius, {Yoram A.} and Mahoney, {Nicole M.} and Almo, {Steven C.}",

note = "Funding Information: We thank KC Holmes, PJ McLaughlin, and R Robinson for the coordinates of the actin filament, the actin:gelsolin 1 complex, and full-length horse plasma gelsolin, respectively. A Bresnick, J Condeelis and P Matsudaira provided helpful comments on the manuscript. Diagrams were drawn with the programs MOLSCRIPT \[98\]G, RASP \[99\]a nd SETOR \[100\]. This work is supported by the National Insitutes for Health (NIH grants GM53807 and AR44417) to SCA. YAP is supported by an MSTP training grant T32 (NIH grant GM07288) from the National Institutes for Health.",

year = "1998",

month = feb,

doi = "10.1016/S0955-0674(98)80083-5",

language = "English (US)",

volume = "10",

pages = "23--34",

journal = "Current Opinion in Cell Biology",

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T1 - The modular structure of actin-regulatory proteins

AU - Puius, Yoram A.

AU - Mahoney, Nicole M.

AU - Almo, Steven C.

N1 - Funding Information: We thank KC Holmes, PJ McLaughlin, and R Robinson for the coordinates of the actin filament, the actin:gelsolin 1 complex, and full-length horse plasma gelsolin, respectively. A Bresnick, J Condeelis and P Matsudaira provided helpful comments on the manuscript. Diagrams were drawn with the programs MOLSCRIPT \[98\]G, RASP \[99\]a nd SETOR \[100\]. This work is supported by the National Insitutes for Health (NIH grants GM53807 and AR44417) to SCA. YAP is supported by an MSTP training grant T32 (NIH grant GM07288) from the National Institutes for Health.

PY - 1998/2

Y1 - 1998/2

N2 - Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The site-specific assembly and disassembly of these structures are directed by actin-regulatory proteins. This article reviews how structural studies are now defining the atomic details of small modular domains present in actin-regulatory proteins responsible for crosslinking, severing and capping of actin filaments, as well as for localization of actin filament assembly. These studies have identified three modular strategies for the design of proteins that regulate the actin cytoskeleton.

AB - Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The site-specific assembly and disassembly of these structures are directed by actin-regulatory proteins. This article reviews how structural studies are now defining the atomic details of small modular domains present in actin-regulatory proteins responsible for crosslinking, severing and capping of actin filaments, as well as for localization of actin filament assembly. These studies have identified three modular strategies for the design of proteins that regulate the actin cytoskeleton.

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The modular structure of actin-regulatory proteins

Abstract

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