The modular structure of actin-regulatory proteins

Yoram A. Puius, Nicole M. Mahoney, Steven C. Almo

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The site-specific assembly and disassembly of these structures are directed by actin-regulatory proteins. This article reviews how structural studies are now defining the atomic details of small modular domains present in actin-regulatory proteins responsible for crosslinking, severing and capping of actin filaments, as well as for localization of actin filament assembly. These studies have identified three modular strategies for the design of proteins that regulate the actin cytoskeleton.

Original languageEnglish (US)
Pages (from-to)23-34
Number of pages12
JournalCurrent Opinion in Cell Biology
Issue number1
StatePublished - Feb 1998

ASJC Scopus subject areas

  • Cell Biology


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