The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity

Naja Attia, William V. Tamborlane, Rubina Heptulla, David Maggs, Aida Grozman, Robert S. Sherwin, Sonia Caprio

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Although low GH levels are commonly seen in obese adults and children, the effects of obesity on the insulin-like growth factor (IGF)/IGF-binding protein (IGFBP) system have not been established. As GH and IGF-I normally increase during adolescence, we investigated the effects of obesity on circulating total and free IGF-I levels and IGFBP-1, -2, and -3 in 19 obese adolescents [14 ± 1 yr old; body mass index (BMI), 34 ± 3], 20 lean adolescents (14 ± 1 yr old; BMI, 23 ± 0.5), and 10 lean adults (22 ± 0.7 yr; BMI, 22 ± 0.7). Fasting plasma insulin levels were significantly greater in obese adolescents than in either lean group, whereas circulating IGFBP-1 levels were suppressed in an inverse relationship to basal insulin (r = - 0.49; P < 0.01). Low IGFBP-1 levels were associated with normal to increased free IGF-I levels in obese adolescents, even though total IGF-I values were lower than those in lean adolescents. Basal GH and IGFBP-3 levels were also lower in obese vs. lean adolescents. Basal IGFBP-1 levels were markedly reduced in obese adolescents (14 ± 3 ng/mL) vs. those in adolescents and adults. No further suppression of IGFBP-1 levels was observed in the obese group during a two-step 8 and 40 mU/m2 insulin clamp. In contrast, IGFBP-1 levels were promptly lowered in lean adults. Basal IGFBP-2 levels were significantly lower in both groups of adolescents vs. lean adults (P < 0.05), and IGFBP-2 levels did not change during euglycemic hyperinsulinemia. These data suggest that the compensatory hyperinsulinemia that characterizes adolescent obesity chronically suppresses levels of IGFBP-1, and low IGFBP-1 concentrations may serve to increase the bioavailability of free IGF-I, which may, in turn, contribute to lower circulating GH, total IGF-I, and IGFBP-3 concentrations.

Original languageEnglish (US)
Pages (from-to)1467-1471
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume83
Issue number5
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor Binding Protein 1
Pediatric Obesity
Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Protein 3
Insulin
Body Mass Index
Hyperinsulinism
Insulin-Like Growth Factor Binding Proteins
Clamping devices
Somatomedins
Biological Availability
Fasting
Plasmas
Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Attia, N., Tamborlane, W. V., Heptulla, R., Maggs, D., Grozman, A., Sherwin, R. S., & Caprio, S. (1998). The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity. Journal of Clinical Endocrinology and Metabolism, 83(5), 1467-1471. https://doi.org/10.1210/jc.83.5.1467

The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity. / Attia, Naja; Tamborlane, William V.; Heptulla, Rubina; Maggs, David; Grozman, Aida; Sherwin, Robert S.; Caprio, Sonia.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 83, No. 5, 1998, p. 1467-1471.

Research output: Contribution to journalArticle

Attia, N, Tamborlane, WV, Heptulla, R, Maggs, D, Grozman, A, Sherwin, RS & Caprio, S 1998, 'The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity', Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 5, pp. 1467-1471. https://doi.org/10.1210/jc.83.5.1467
Attia, Naja ; Tamborlane, William V. ; Heptulla, Rubina ; Maggs, David ; Grozman, Aida ; Sherwin, Robert S. ; Caprio, Sonia. / The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity. In: Journal of Clinical Endocrinology and Metabolism. 1998 ; Vol. 83, No. 5. pp. 1467-1471.
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